248 chapter 2 Table 58. Estimated pooled test performance of (semi-)quantitative elastosonography in indeterminate thyroid nodules ni test + test - test ? nH (%) TP FP FN TN malignant (TP+FN/ni) sensitivity (95% CI), % specificity (95% CI), % LR+ (95% CI) LR- (95% CI) Cantisani 2012 140 43 97 140 (100%) 35 8 5 92 29% 88 (73-96) 92 (85-96) 10.94 (5.57-21.48) 0.14 (0.06-0.31) Russ 2013 34 7 27 34 (100%) 1 6 8 19 26% 11 (0-48) 76 (55-91) 0.46 (0.06-3.34) 1.17 (0.85-1.61) Cakir 2014 (2) 270 87 183 270 (100%) 80 7 1 182 30% 99 (93-100) 96 (93-98) 26.67 (12.88-55.19) 0.01 (0.00-0.09) Abdelrahman 2015 (2) 73 16 57 73 (100%) 16 0 0 57 22% 100 (79-100) 100 (94-100) 112.59 (7.12-1780.79) 0.03 (0.00-0.46) Cantisani 2015 315 93 222 315 (100%) 77 16 8 214 27% 91 (82-96) 93 (89-96) 13.02 (8.08-20.99) 0.10 (0.05-0.20) Samir 2015 35 12 23 35 (100%) 9 3 2 21 31% 82 (48-98) 88 (68-97) 6.55 (2.19-19.56) 0.21 (0.06-0.73) POOLED RESULTS 867 258 609 0 867 (100%) 218 40 24 585 27.9% 92.1 (53.6-99.2) 93.4 (85.5-97.2) 14.04 (5.22-37.79) 0.08 (0.01-0.75) FN: false negative. FP: false positive. LR+: positive likelihood ratio. LR-: negative likelihood ratio. nH: number of indeterminate thyroid nodules with conclusive index test and histopathological follow-up. ni: number of indeterminate thyroid nodules. test+: number of positive index tests. test-: number of negative index tests. test?: number of unknown or nondiagnostic index tests. TN: true negative. TP: true positive.
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