238 chapter 2 (95% CI: 91.4%-99.8%), 17.6% (95% CI: 2.7%-61.6%), 1.20 (95% CI: 0.84-1.70) and 0.08 (95% CI: 0.010.73), respectively. The AUC is 0.94 (95% CI: 0.92-0.96) (Table 57, Figure 78 and Figure 79). For a given prevalence of malignancy of 15%, 25% or 40%, these results correspond to an estimated PPV and NPV Table 54. Baseline characteristics of included studies investigating elastosonography reference country study design ntot ni femalei agei, y sizei, mm included indeterminate cytology Rago 2010 Italy RS 195 142 n.s. n.s. n.s. indeterminate Lippolis 2011 Italy PS 102 102 68% median 47 (19-73) median 22; range 7-100 indeterminate Cantisani 2012 Italy PS 140 140 91% median 38 (17-78) mean 18 ±11; range 5-50 Thy3 Ragazzoni 2012 Italy PS 132 24 n.s. n.s. n.s. Thy3 Trimboli 2012 Italy PS 498 42 n.s. n.s. n.s. Thy3 Ünlütürk 2012 Turkey PS 237 18 n.s. n.s. n.s. indeterminate Mohey 2013 Egypt PS 46 16 n.s. n.s. n.s. indeterminate or follicular lesion Russ 2013 France PS 263 34 n.s. n.s. n.s. Bethesda III or IV Cakir 2014 Turkey PS 270 270 95% mean 48 ±11 n.s. Bethesda III AUS Abdelrahman 2015 Egypt PS 73 73 82% 19-78 n.s. indeterminate (follicular) cytology Cantisani 2015 Italy PS 315 315 66% mean 56 (1884) n.s. Thy3 Garino 2015 Italy PS 108 108 75% median 50 n.s. Thy3 Samir 2015 USA PS 35 35 66% mean 55 ±16 range 10-53 Bethesda III or IV Piccardo 2016 Italy PS 87 70 74% mean 57 ± 13 mean 24 ±13 TIR 3 TOTAL 2,501 1,389 i: applies to indeterminate thyroid nodules only. ni: number of indeterminate thyroid nodules. n.s.: not specified. ntot: total number of thyroid nodules in study. PS: prospective. RS: retrospective. TN: thyroid nodule. USE: ultrasound elastography. y: years.
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