220 chapter 2 Figure 66. Estimated pooled test performance of individual ultrasound characteristics (continued) Estimated pooled sensitivity, specificity, positive and negative likelihood ratios with their corresponding 95% confidence intervals of individual ultrasound characteristics in indeterminate thyroid nodules with available histopathological follow-up, including Bethesda III and IV subgroups. *: pooled results estimated using random effects model in case the number of studies is smaller than 4. CI, confidence interval; n.a., not applicable; n.a.c., not able to calculate. positive likelihood ratio (95% CI) 0 5 2 1 3 1.06 (0.77-1.45) n.a.c. 0.98 (0.54-1.78) 1.17 (1.09-1.25) 1.13 (1.07-1.19) 1.05 (0.91-1.20) 1.63 (1.39-1.92) 2.46 (1.59-3.79) 1.53 (1.16-2.01) 1.62 (1.01-2.59) n.a. 1.75 (1.02-2.97) 3.72 (2.37-5.84) 3.36 (2.17-5.21) 4.69 (1.45-15.20) 1.24 (0.93-1.65) 1.49 (0.98-2.25) 1.38 (0.85-2.23)* 3.99 (2.82-5.64) 2.81 (1.99-3.98) 4.63 (1.64-13.10) 1.76 (1.15-2.71) 1.75 (0.72-4.25) 3.57 (1.41-9.05) 2.60 (1.94-3.48) 2.82 (1.53-5.22) 4.38 (2.57-7.47) 1.13 (0.84-1.53) 1.07 (0.82-1.41) 2.78 (0.14-54.57)* 4 Solitary nodule Solid nodule Hypoechogeneity 6L]H FP Taller-than-wide shape Absence of halo ,UUHJXODU PDUJLQ Intranodular vascularisation 0LFURFDOFL¿FDWLRQV 0DFURFDOFL¿FDWLRQV all Bethesda III Bethesda IV all Bethesda III Bethesda IV all Bethesda III Bethesda IV all Bethesda III Bethesda IV all Bethesda III Bethesda IV all Bethesda III Bethesda IV all Bethesda III Bethesda IV all Bethesda III Bethesda IV all Bethesda III Bethesda IV all Bethesda III Bethesda IV 1,569 600 699 3,042 1,518 784 4,276 1,601 1,157 445 0 386 2,129 1,256 637 1,533 694 359 3,969 1,601 947 2,835 1,030 541 4,027 1,331 994 2,275 1,607 172 number of studies ni 13 3 6 27 9 8 33 10 10 6 0 5 15 8 4 13 4 3 28 10 8 21 6 5 31 9 8 18 10 2 82.3% n.a.c. 91.1% 49.4% 0.0% 21.1% 65.6% 59.9% 72.6% 0.0% n.a. 0.0% 43.6% 14.2% n.a.c. 97.8% n.a.c. n.a.c. 72.3% 0.7% 66.7% 88.4% 76.1% 81.7% 62.2% 65.7% 67.4% 0.0% 0.0% n.a.c. i2
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