216 chapter 2 reference country study design ntot ni femalei mean agei, y sizei, mm Kayilioglu 2014 Turkey RS 103 103 83% n.s. benign 52 ± 12 / malignant 54 ± 10 Khoncarly 2014 USA RS 61 61 82% 52 52 ± 15 Lee, KH 2014 South Korea RS 152 152 77% n.s. benign 48 (26-75) / malignant 45 (26-69) Matthey-Gie 2014 Ireland RS 40 40 80% 51 51 Norlén 2014 Australia RS 141 141 86% 55 55 ± 15 Rosario 2014 Brazil PS 150 84 83% n.s. benign 50 / malignant 51 Saiegh 2014 Israel RS 145 145 n.s. n.s. n.s. Tutuncu 2014 Turkey n.s. 201 160 89% 48 48 ± 14 Yoo 2014 South Korea RS 249 249 79% 51 51 ± 12 Yoon 2014 South Korea RS 393 275 83% n.s. benign 50 ± 12 / malignant 47 ± 11 Cantisani 2015 Italy PS 356 315 66% 56 56 (18-84) Garino 2015 Italy PS 108 108 75% n.s. median 50 (IQR 40-60) Kamaya 2015 USA RS 41 41 76% 49 49 (13-76) Macias 2015 USA RS 151 151 74% 52 52 ± 15 Maia 2015 Brazil RS 242 90 n.s. n.s. n.s. Le Mercier 2015 Belgium RS 34 34 85% 44 44 (24-68) Park 2015 South Korea RS 58 58 82% 51 51 (23-76) Samir 2015 USA PS 35 35 66% 55 55 ± 16.1 Brophy 2016 Ireland RS 858 161 n.s. n.s. n.s. Dogan 2016 Turkey RS 124 124 n.s. n.s. AUS/FLUS 48 ± 12 / FN/SFN 47 ± 3 De Napoli 2016 Italy RS 258 258 74% 44 44 (14-78) Piccardo 2016 Italy PS 87 87 74% 57 57 ± 13 Yoon 2016 South Korea RS 192 192 76% 50 50 ± 12 TOTAL 10,298 6,692 Age/size: presented as mean ± standard deviation, or with range between parentheses, unless otherwise specified. AUS: atypia of undetermined significance. FLUS: follicular lesion of undetermined significance. FTC: follicular thyroid carcinoma. FTC-OV: FTC, oncocytic variant (Hürthle cell carcinoma). FVPTC: papillary thyroid carcinoma, follicular variant. i: applies to indeterminate thyroid nodules only. MTC: medullary thyroid carcinoma. ni: total number of indeterminate thyroid nodules included in our analysis. n.s.: not specified. ntot: total number of thyroid nodules in study. PS: prospective. PTC: papillary thyroid carcinoma. RS: retrospective. TN: thyroid nodule. y: years. Ultrasound features: AH: absence of halo. HY: hypoechogenicity. IM: irregular margins. IV: intranodular vascularization. MA: macrocalcifications. MI: microcalcifications. Other: other scoring system. SN: solitary nodule. SO: solid nodule. SS: spherical shape. SZ: nodule size. TI: TIRADS. TW: taller-than-wide shape.
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