208 chapter 2 Table 48. Estimated pooled test performance of positive ICC staining for galectin-3 and/or HBME-1 in indeterminate thyroid nodules ni test + test - test ? nH (%) TP FP FN TN malignant (TP+FN/ni) sensitivity (95% CI), % specificity (95% CI), % LR+ (95% CI) LR- (95% CI) Rossi 2005 37 23 14 37 (100%) 17 6 0 14 46% 100 (80-100) 70 (46-88) 3.14 (1.65-5.98) 0.04 (0.00-0.63) Saggiorato 2005 125 72 53 125 (100%) 73 5 2 45 60% 97 (91-100) 90 (78-97) 9.73 (4.23-22.37) 0.03 (0.01-0.12) Fadda 2011 50 19 31 50 (100%) 10 9 1 30 22% 91 (59-100) 77 (61-89) 3.94 (2.16-7.20) 0.12 (0.02-0.77) Zhang 2015 51 30 21 51 (100%) 21 9 1 20 43% 95 (77-100) 69 (49-85) 3.08 (1.77-5.33) 0.07 (0.01-0.45) POOLED RESULTS 263 144 119 0 263 (100%) 121 29 4 109 47.5% 96.6 (90.8-98.8) 78.6 (67.9-86.4) 4.51 (2.92-6.97) 0.04 (0.01-0.12) FN: false negative. FP: false positive. LR+: positive likelihood ratio. LR-: negative likelihood ratio. nH: number of indeterminate thyroid nodules with conclusive index test and histopathological follow-up. ni: number of indeterminate thyroid nodules. test+: number of positive index tests. test-: number of negative index tests. test?: number of unknown or nondiagnostic index tests. TN: true negative. TP: true positive. Table 49. Estimated pooled test performance of simultaneous positive ICC staining for galectin-3 and HBME-1 in indeterminate thyroid nodules ni test+ test - test ? nH (%) TP FP FN TN malignant (TP+FN/ni) sensitivity (95% CI), % specificity (95% CI), % LR+ (95% CI) LR- (95% CI) Rossi 2005 37 18 19 37 (100%) 14 4 3 16 46% 82 (57-96) 80 (56-94) 4.12 (1.67-10.17) 0.22 (0.08-0.63) Saggiorato 2005 125 56 69 125 (100%) 56 0 19 50 60% 75 (63-84) 100 (93-100) 75.83 (4.79-1199.70) 0.26 (0.18-0.38) Fadda 2011 50 19 31 50 (100%) 10 3 1 36 22% 91 (59-100) 84 (60-97) 5.76 (2.00-16.54) 0.11 (0.02-0.71) Zhang 2015 51 30 21 51 (100%) 12 1 10 28 43% 55 (32-76) 97 (82-100) 15.82 (2.22-112.67) 0.47 (0.30-0.75) POOLED RESULTS 263 123 140 0 263 (100%) 92 8 33 130 47.5% 76.7 (62.2-86.8) 94.3 (79.4-98.6) 13.47 (3.60-50.42) 0.25 (0.15-0.41) FN: false negative. FP: false positive. LR+: positive likelihood ratio. LR-: negative likelihood ratio. nH: number of indeterminate thyroid nodules with conclusive index test and histopathological follow-up. ni: number of indeterminate thyroid nodules. test+: number of positive index tests. test-: number of negative index tests. test?: number of unknown or nondiagnostic index tests. TN: true negative. TP: true positive.
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