205 Diagnostic utility of molecular and imaging biomarkers 2 Figure 57. SROC curve of HBME-1 ICC Summary receiver operating characteristic plot showing sensitivity versus 1-specificity of HBME-1 ICC in indeterminate thyroid nodules with available histopathology. AUC = 0.92 (95% CI: 0.89-0.94). AUC, area under the curve; HSROC, hierarchical summary receiver operating characteristic. Figure 58. Bayesian probability plot of HBME-1 ICC Bayesian conditional probability plot showing the post-test probabilities versus prior probabilities of HBME-1 ICC to predict malignancy in indeterminate thyroid nodules, using the estimated summary likelihood ratios. Positive LR = 6.77 (95% CI: 4.46-10.27). Negative LR = 0.22 (95% CI: 0.14-0.36).
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