200 chapter 2 Table 45. Estimated pooled test performance of galectin-3 ICC in indeterminate thyroid nodules ni test + test - test ? nH (%) TP FP FN TN malignant (TP+FN/ni) sensitivity (95% CI), % specificity (95% CI), % LR+ (95% CI) LR- (95% CI) Collet 2005 34 11 23 34 (100%) 9 2 3 20 35% 75 (43-95) 91 (71-99) 8.25 (2.11-32.18) 0.28 (0.10-0.74) Mills 2005 13 1 4 8 4 (80%) 1 0 2 1 23% 33 (1-91) 100 (3-100) 1.50 (0.10-22.62) 0.83 (0.28-2.51) Rossi 2005 37 20 17 37 (100%) 15 5 2 15 46% 88 (64-99) 75 (51-91) 3.53 (1.62-7.69) 0.16 (0.04-0.59) Saggiorato 2005 125 72 53 125 (100%) 69 3 6 47 60% 92 (83-97) 94 (83-99) 15.33 (5.11-46.02) 0.09 (0.04-0.18) Sapio 2007 (1) 47 5 42 20 (43%) 0 0 2 18 4% 0 (0-84) 100 (81-100) 6.33 (0.15-262.92) 0.86 (0.51-1.43) Aiad 2008 17 4 13 17 (100%) 4 0 2 11 35% 67 (22-96) 100 (72-100) 15.43 (0.97-245.99) 0.37 (0.14-1.01) Bartolazzi 2008 465 134 331 465 (100%) 112 22 51 280 35% 69 (61-76) 93 (89-95) 9.43 (6.23-14.29) 0.34 (0.27-0.42) Pennelli 2009 100 24 76 100 (100%) 12 12 3 73 15% 80 (52-96) 86 (77-92) 5.67 (3.17-10.14) 0.23 (0.08-0.64) Asioli 2010 53 25 38 53 (84%) 17 8 11 17 53% 61 (41-78) 68 (46-85) 1.90 (1.00-3.61) 0.58 (0.34-0.98) Raggio 2010 60 16 44 60 (100%) 16 0 13 31 48% 55 (36-74) 100 (89-100) 35.20 (2.21-561.21) 0.46 (0.31-0.68) Fadda 2011 50 14 36 50 (100%) 10 4 1 35 22% 91 (59-100) 90 (76-97) 8.86 (3.44-22.85) 0.10 (0.02-0.66) Zhang 2015 51 25 26 51 (100%) 17 8 5 21 43% 77 (55-92) 72 (53-87) 2.80 (1.49-5.27) 0.31 (0.14-0.70) POOLED RESULTS 1,052 346 661 8 1,016 (96.4%) 282 64 101 569 36.4% 73.9 (62.6-82.8) 90.7 (82.7-95.2) 7.97 (4.25-14.95) 0.29 (0.20-0.42) FN: false negative. FP: false positive. LR+: positive likelihood ratio. LR-: negative likelihood ratio. nH: number of indeterminate thyroid nodules with conclusive index test and histopathological follow-up. ni: number of indeterminate thyroid nodules. test+: number of positive index tests. test-: number of negative index tests. test?: number of unknown or nondiagnostic index tests. TN: true negative. TP: true positive.
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