19 General introduction and outline of this thesis 1 diagnostics is compared to [18F]FDG-PET/CT in indeterminate thyroid nodules for the first time, using the EfFECTS trial cohort. This chapter also discusses the therapeutic efficacy of the combined use of both techniques, presents how to prevent the waste of valuable resources by choosing the right (order of) diagnostic test(s) for the non-oncocytic or oncocytic indeterminate cytology subgroups, and assesses whether molecular alterations drive the differences in [18F]FDG uptake that is observed among benign nodules. In Part IV, the epilogue, this thesis concludes with a general discussion on the studies presented in this work and future prospects.
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