188 chapter 2 Figure 49. Estimated pooled test performance of the Afirma® GEC – second-best-case scenario Forest plots showing the estimated pooled sensitivity, specificity, positive and negative likelihood ratios with their corresponding 95% confidence intervals of the Afirma® GEC in a hypothetical second-best-case scenario in which we presumed 6% (missed) malignancies in indeterminate thyroid nodules without available histopathological correlation. In all other cases without histopathological correlation, we assumed that the nodule was benign. CI, confidence interval; df, degrees of freedom; DLR positive, positive diagnostic likelihood ratio; DLR negative, negative diagnostic likelihood ratio; I2, heterogeneity statistic I2; Q, Cochran’s Q.
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