186 chapter 2 Figure 46. SROC curve of the Afirma® GEC – best-case scenario Summary receiver operating characteristic plot showing sensitivity versus 1-specificity of the Afirma® GEC in a hypothetical bestcase scenario in which we presumed that the Afirma® GEC was always right in indeterminate thyroid nodules without available histopathology. AUC = 0.94 (95% CI: 0.92-0.96). AUC, area under the curve; HSROC, hierarchical summary receiver operating characteristic. Figure 48. SROC curve of the Afirma® GEC – worst-case scenario Summary receiver operating characteristic plot showing sensitivity versus 1-specificity of the Afirma® GEC in a hypothetical worst-case scenario in which we presumed that the Afirma® GEC was always false in indeterminate thyroid nodules without available histopathological correlation. AUC = 0.13 (95% CI: 0.11-0.17). AUC, area under the curve; HSROC, hierarchical summary receiver operating characteristic.
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