175 Diagnostic utility of molecular and imaging biomarkers 2 Figure 39. SROC curve of the Afirma® GEC Summary receiver operating characteristic plot showing sensitivity versus 1-specificity of the Afirma® GEC in indeterminate thyroid nodules with available histopathology. AUC = 0.85 (95% CI: 0.82-0.88). AUC, area under the curve; HSROC, hierarchical summary receiver operating characteristic. Figure 40. Bayesian probability plot of the Afirma® GEC Bayesian conditional probability plot showing the post-test probabilities versus prior probabilities of the Afirma® GEC to predict malignancy in indeterminate thyroid nodules, using the estimated summary likelihood ratios. Positive LR = 1.15 (95% CI: 1.06-1.23). Negative LR = 0.18 (95% CI: 0.09-0.37).
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