166 chapter 2 Table 29. Estimated pooled test performance of a 7-gene mutation panel in Bethesda III thyroid nodules ni Beth III test + test - test ? nH (%) TP FP FN TN malignant (TP+FN/ni) sensitivity (95% CI), % specificity (95% CI), % Nikiforov 2011* 247 25 222 247 (100%) 22 3 13 209 14% 63 (46-77) 99 (96-100) Beaudenon-Huibregtse 2014* 42 8 34 22 (52%) 4 2 7 9 26% 36 (15-65) 82 (52-95) Valderrabano 2016* 47 0 43 4 19 (44%) 0 0 3 16 6% 0 (0-56) 100 (81-100) TOTAL 336 33 299 4 288 (86.7%) 26 5 23 234 14.6% 35 (0-71) 98 (96-100) *: study applied miRInform® test. FN: false negative. FP: false positive. LR+: positive likelihood ratio. LR-: negative likelihood ratio. nH: number of indeterminate thyroid nodules with conclusive index test and histopathological follow-up. ni: number of indeterminate thyroid nodules. test+: number of positive index tests. test-: number of negative index tests. test?: number of unknown or nondiagnostic index tests. TN: true negative. TP: true positive. Table 30. Estimated pooled test performance of a 7-gene mutation panel in Bethesda IV thyroid nodules ni Beth IV test + test - test ? nH (%) TP FP FN TN malignant (TP+FN/ni) sensitivity (95% CI), % specificity (95% CI), % LR+ (95% CI) LR- (95% CI) Nikiforov 2011* 214 38 176 214 (100%) 33 5 25 151 27% 57 (43-70) 97 (93-99) 17.75 (7.28-43.27) 0.45 (0.33-0.60) Ohori 2013* 424 64 320 40 384 (100%) 60 4 54 266 27% 53 (43-62) 99 (96-100) 35.53 (13.23-95.43) 0.48 (0.40-0.58) Beaudenon-Huibregtse 2014* 38 6 32 19 (50%) 4 1 2 12 16% 67 (22-96) 92 (64-100) 8.67 (1.21-61.91) 0.36 (0.12-1.13) Giovanella 2015 61 7 54 61 (100%) 4 3 12 42 26% 25 (7-52) 93 (82-99) 3.75 (0.94-14.97) 0.80 (0.60-1.08) Valderrabano 2016* 58 15 40 3 37 (64%) 10 3 6 18 28% 62 (35-85) 86 (64-97) 4.38 (1.44-13.33) 0.44 (0.23-0.84) TOTAL 795 130 622 43 715 (95.1%) 111 16 99 489 26.4% 52.6 (43.8-61.2) 96.0 (91.3-98.2) 13.1 (5.83-29.3) 0.49 (0.41-0.60) *: study applied miRInform® test. FN: false negative. FP: false positive. LR+: positive likelihood ratio. LR-: negative likelihood ratio. nH: number of indeterminate thyroid nodules with conclusive index test and histopathological follow-up. ni: number of indeterminate thyroid nodules. test+: number of positive index tests. test-: number of negative index tests. test?: number of unknown or nondiagnostic index tests. TN: true negative. TP: true positive.
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