161 Diagnostic utility of molecular and imaging biomarkers 2 Figure 31. SROC curve of 7-gene mutation panels Summary receiver operating characteristic plot showing sensitivity versus 1-specificity of 7-gene mutation panels in indeterminate thyroid nodules with available histopathology. AUC = 0.78 (95% CI: 0.74-0.82). AUC, area under the curve; HSROC, hierarchical summary receiver operating characteristic. Figure 32. Bayesian probability plot of 7-gene mutation panels Bayesian conditional probability plot showing the post-test probabilities versus prior probabilities of 7-gene mutation panels to predict malignancy in indeterminate thyroid nodules, using the estimated summary likelihood ratios. Positive LR = 7.22 (95% CI: 4.08-12.76). Negative LR = 0.56 (95% CI: 0.46-0.68).
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