149 Diagnostic utility of molecular and imaging biomarkers 2 Figure 24. SROC curve of BRAF/ RAS mutation analysis Summary receiver operating characteristic plot showing sensitivity versus 1-specificity of BRAF/RAS mutation analysis in indeterminate thyroid nodules with available histopathology. AUC = 0.88 (95% CI: 0.85-0.90). AUC, area under the curve; HSROC, hierarchical summary receiver operating characteristic. Figure 25. Bayesian probability plot of BRAF/RAS mutation analysis Bayesian conditional probability plot showing the post-test probabilities versus prior probabilities of BRAF/ RAS mutation analysis to predict malignancy in indeterminate thyroid nodules, using the estimated summary likelihood ratios. Positive LR = 8.69 (95% CI: 5.41-13.96). Negative LR = 0.55 (95% CI: 0.45-0.68).
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