146 chapter 2 Table 21. Cytological BRAF/RAS mutation status in histopathologically confirmed malignancies BRAF or RAS mutation positive malignancies, ni BRAF or RAS mutation negative malignancies, ni PTC FVPTC FTC FTC-OV MTC mPTC other n.s. PTC FVPTC FTC FTC-OV MTC mPTC other n.s. Cantara 2010 4 3 Moses 2010 3 4 16 4 2 Nikiforov 2011 10 39 3 5 30 6 Mancini 2012 2 2 5 Ohori 2013 1 46 1 1 1 3 5 50 3 1 1 1 Beaudenon 2014 8 3 5 1 Danilovic 2014 19 11 Eszlinger 2014 (1) 2 2 2 16 Eszlinger 2014 (2) 1 3 5 Liu 2014 3 1 2 2 Nikiforov 2014 21 18 Eszlinger 2015 5 5 10 1 1 2 6 11 4 Gill 2015 10 13 Giovanella 2015 1 1 1 2 2 4 5 Hwang 2015 37 32 1 3 9 1 Le Mercier 2015 1 1 2 1 1 1 Nikiforov 2015 13 9 Rossi 2015 13 1 3 1 Valderrabano 2016 7 1 1 6 1 1 1 1 TOTAL 86 133262 1 0 66632127 5515 1 1 3 56 FTC: follicular thyroid carcinoma. FTC-OV: FTC, oncocytic variant (Hürthle cell carcinoma). FVPTC: papillary thyroid carcinoma, follicular variant. mPTC: papillary thyroid microcarcinoma. MTC: medullary thyroid carcinoma. n.s.: not specified. PTC: papillary thyroid carcinoma. FN: false negative. FP: false positive. LR+: positive likelihood ratio. LR-: negative likelihood ratio. nH: number of indeterminate thyroid nodules with conclusive index test and histopathological follow-up. ni: number of indeterminate thyroid nodules. test+: number of positive index tests. test-: number of negative index tests. test?: number of unknown or nondiagnostic index tests. TN: true negative. TP: true positive.
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