140 chapter 2 Table 19. Estimated pooled test performance of PAX8/PPARγ rearrangement analysis in indeterminate thyroid nodules ni test + test - test ? nH (%) TP FP FN TN malignant (TP+FN/ni) sensitivity (95% CI), % specificity (95% CI), % LR+ (95% CI) LR- (95% CI) French 2008 13 2 11 0 13 (100%) 2 0 5 6 54% 29 (4-71) 100 (54-100) 4.38 (0.25-76.54) 0.74 (0.44-1.23) Cantara 2010 41 0 41 0 41 (100%) 0 0 7 34 17% 0 (0-41) 100 (90-100) 4.38 (0.09-204.35) 0.95 (0.79-1.14) Nikiforov 2011 461 3 458 0 461 (100%) 3 0 90 368 20% 3 (1-9) 100 (99-100) 27.48 (1.43-527.39) 0.96 (0.93-1.00) Mancini 2012 48 0 48 0 38 (79%) 0 0 9 29 19% 0 (0-34) 100 (88-100) 3.00 (0.06-141.55) 0.97 (0.83-1.12) Ohori 2013 424 7 377 40 384 (100%) 7 0 107 270 30% 6 (3-12) 100 (99-100) 35.35 (2.04-613.77) 0.94 (0.89-0.98) BeaudenonHuibregtse 2014 80 2 78 0 41 (51%) 0 1 17 23 21% 0 (0-20) 96 (79-100) 0.46 (0.02-10.73) 1.03 (0.91-1.17) Eszlinger 2014 (1) 164 6 135 23 141 (100%) 2 4 20 115 15% 9 (1-29) 97 (92-99) 2.70 (0.53-13.88) 0.94 (0.82-1.08) Eszlinger 2014 (2) 125 2 123 0 64 (51%) 1 1 8 54 7% 11 (0-48) 98 (90-100) 6.11 (0.42-89.20) 0.91 (0.72-1.14) Nikiforov 2014 143 4 139 0 143 (100%) 4 0 35 104 27% 10 (3-24) 100 (97-100) 23.62 (1.30-428.92) 0.89 (0.80-1.00) Eszlinger 2015 163 0 158 5 158 (100%) 0 0 45 113 28% 0 (0-8) 100 (97-100) 2.48 (0.05-123.04) 0.99 (0.96-1.03) Giovanella 2015 61 3 58 0 61 (100%) 1 2 15 43 26% 6 (0-30) 96 (85-99) 1.41 (0.14-14.48) 0.98 (0.85-1.13) Nikiforov 2015 462 1 461 0 95 (21%) 1 0 21 73 5% 5 (0-23) 100 (95-100) 9.65 (0.41-228.93) 0.94 (0.84-1.05) Valderrabano 2016 105 2 96 7 56 (57%) 2 0 17 37 18% 11 (1-33) 100 (91-100) 9.50 (0.48-188.48) 0.89 (0.75-1.05) POOLED RESULTS 2,290 32 2,183 75 1,696 (76.6%) 23 8 396 1,269 18.3% 5.9 (3.8-9.0) 99.7 (98.1-100) 19.44 (3.17-119.27) 0.94 (0.92-0.97) FN: false negative. FP: false positive. LR+: positive likelihood ratio. LR-: negative likelihood ratio. nH: number of indeterminate thyroid nodules with conclusive index test and histopathological follow-up. ni: number of indeterminate thyroid nodules. test+: number of positive index tests. test-: number of negative index tests. test?: number of unknown or nondiagnostic index tests. TN: true negative. TP: true positive.
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