137 Diagnostic utility of molecular and imaging biomarkers 2 Table 16. Results of RET/PTC rearrangement analysis in indeterminate nodules ni test + test - test ? nH (%) TP FP FN TN malignant (TP+FN/ni) Sapio 2007 (2) 21 0 21 0 20 (95%) 0 0 2 18 17% Cantara 2010 41 2 39 0 41 (100%) 2 0 5 34 17% Moses 2010 110 1 109 0 110 (100%) 1 0 28 81 26% Guerra 2011 24 2 22 0 24 (100%) 0 2 10 12 42% Nikiforov 2011 461 0 461 0 461 (100%) 0 0 93 368 20% Mancini 2012 48 1 47 0 38 (79%) 1 0 8 29 19% Ohori 2013 424 0 384 40 384 (100%) 0 0 114 270 27% BeaudenonHuibregtse 2014 80 0 80 0 41 (51%) 0 0 17 24 21% Eszlinger 2014 (1) 164 0 141 23 141 (100%) 0 0 22 119 13% Eszlinger 2014 (2) 125 1 124 0 64 (51%) 1 0 8 55 7% Liu 2014 52 0 50 2 50 (100%) 0 0 8 42 15% Nikiforov 2014 143 0 143 0 143 (100%) 0 0 39 104 27% Eszlinger 2015 163 0 158 5 158 (100%) 0 0 45 113 28% Giovanella 2015 61 0 61 0 61 (100%) 0 0 16 45 26% Nikiforov 2015 462 0 462 0 95 (21%) 0 0 22 73 5% Rossi 2015 118 9 109 0 40 (34%) 2 6 16 16 15% Valderrabano 2016 105 1 97 7 56 (57%) 1 0 18 37 18% TOTAL 2,602 17 2,508 77 1,927 (76.3%) 8 8 471 1,440 18.4% FN: false negative. FP: false positive. nH: number of indeterminate thyroid nodules with conclusive index test and histopathological follow-up. ni: number of indeterminate thyroid nodules. test+: number of positive index tests. test-: number of negative index tests. test?: number of unknown or nondiagnostic index tests. TN: true negative. TP: true positive.
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