135 Diagnostic utility of molecular and imaging biomarkers 2 other inclusion and exclusion criteria FNAC sample molecular technique TN; indeterminate cytology on two consecutive FNACs; histological f/u available additional FNAC aspirate RT-PCR with primers TN; histological f/u available additional pre-operative US-FNAC n.o.s. primary and nested PCR amplification TN; FNAC sample with adequate nucleic acids FNAC sample n.o.s. Nested PCR TN; histological f/u available FNAC sample n.o.s. RT-PCR and Southern Blot TN; FNAC with sufficient epithelial cells and nucleic acids for molecular analysis; histological f/u available residual material from FNAC and needle washout miRInform® Thyroid Test suspicious TN >5mm, FNAC sample positive for thyroglobulin FNAC needle wash-out real-time PCR and FMCA TN; no Hürthle cell cytology; histological f/u available FNAC needle wash-out miRInform® Thyroid Test adult with TN ≥1cm; FNAC with sufficient nucleic acids for molecular analysis; correct specimen handling and shipping; no duplicate or contaminated specimen additional FNAC aspirate miRinform® Thyroid Test TN; air-dried FNAC slide available; histological f/u and FFPE samples available for mutation analysis air-dried FNAC smears multiplex qPCR TN n.o.s. air-dried FNAC smears multiplex RT-qPCR TN; sufficient DNA quality and quantity FNAC needle wash-out TaqMan real-time PCR TN; sufficient nucleic acids for molecular analysis; histological f/u available residual material from two FNAC passes ThyroSeq® v2 TN; size >1cm; histological f/u available air-dried FNAC smears multiplex RT-qPCR and FMCA adult with solitary cold TN ≥10mm; suspicious on US; normal TSH and calcitonin; histologic f/u available representative archived FNAC slide RT-PCR TN n.o.s. residual material from 1 or 2 FNAC passes ThyroSeq® v2.1 TN; suspicious US features; histological or cytological f/u available additional needle pass real-time RT-PCR TN n.o.s. n.s. miRinform® Thyroid Test
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