110 chapter 2 Figure 6. SROC curve of BRAF mutation analysis Summary receiver operating characteristic plot showing sensitivity versus 1-specificity of BRAF mutation analysis in indeterminate thyroid nodules with available histopathology. AUC = 0.92 (95% CI: 0.90-0.94). AUC, area under the curve; HSROC, hierarchical summary receiver operating characteristic. Figure 7. Bayesian probability plot of BRAF mutation analysis Bayesian conditional probability plot showing the post-test probabilities versus prior probabilities of BRAF mutation analysis to predict malignancy in indeterminate thyroid nodules, using the estimated summary likelihood ratios. Positive LR = 193.72 (95% CI: 27.09-1385.38). Negative LR = 0.80 (95% CI: 0.73-0.88). FTC: follicular thyroid carcinoma. FTC-OV: FTC, oncocytic variant (Hürthle cell carcinoma). FVPTC: papillary thyroid carcinoma, follicular variant. mPTC: papillary thyroid microcarcinoma. MTC: medullary thyroid carcinoma. n.s.: not specified. PTC: papillary thyroid carcinoma.
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