108 chapter 2 Table 4. Estimated pooled test performance of BRAF mutation analysis in indeterminate thyroid nodules (continued) ni test + test - test ? nH (%) TP FP FN TN Le Mercier 2015 34 1 33 34 (100%) 1 0 6 27 Nikiforov 2015 462 2 460 95 (21%) 2 0 20 73 Park 2015 20 4 16 13 (65%) 4 0 5 4 Rossi 2015 118 13 105 40 (34%) 13 0 5 22 Beisa 2016 125 7 118 125 (100%) 7 0 20 98 Kowalska 2016 135 3 132 85 (63%) 3 0 5 77 Valderrabano 2016 105 0 105 56 (53%) 0 0 19 37 POOLED RESULTS 6,156 494 5,577 85 3,886 (64.0%) 417 8 897 2,564 FN: false negative. FP: false positive. LR+: positive likelihood ratio. LR-: negative likelihood ratio. nH: number of indeterminate thyroid nodules with conclusive index test and histopathological follow-up. ni: number of indeterminate thyroid nodules. test+: number of positive index tests. test-: number of negative index tests. test?: number of unknown or nondiagnostic index tests. TN: true negative. TP: true positive. Figure 5. Estimated pooled test performance of BRAF mutation analysis
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