107 Diagnostic utility of molecular and imaging biomarkers 2 malignant (TP+FN/ni) sensitivity (95% CI), % specificity (95% CI), % LR+ (95% CI) LR- (95% CI) 52% 15 (2-45) 100 (72-100) 4.29 (0.23-80.81) 0.86 (0.65-1.12) 4% 50 (1-99) 100 (81-100) 19.00 (0.98-366.64) 0.51 (0.17-1.60) 10% 0 (0-84) 100 (81-100) 6.33 (0.15-262.92) 0.86 (0.51-1.43) 78% 62 (38-82) 100 (54-100) 8.59 (0.58-126.75) 0.42 (0.24-0.73) 30% 67 (22-96) 100 (77-100) 19.29 (1.20-311.05) 0.37 (0.14-1.00) 15% 0 (0-71) 100 (80-100) 4.50 (0.10-194.67) 0.90 (0.62-1.31) 17% 29 (4-71) 100 (90-100) 21.88 (1.16-412.80) 0.70 (0.44-1.11) 26% 10 (2-27) 100 (96-100) 19.13 (1.02-359.59) 0.89 (0.78-1.01) 32% 59 (39-78) 100 (84-100) 25.93 (1.65-408.65) 0.42 (0.27-0.66) 15% 62 (32-86) 100 (74-100) 15.79 (1.01-247.04) 0.41 (0.21-0.79) 24% 83 (67-94) 93 (66-100) 11.67 (1.75-77.56) 0.18 (0.09-0.38) 20% 8 (3-15) 100 (99-100) 58.88 (3.39-1,021.77) 0.92 (0.87-0.98) 55% 0 (0-28) 100 (66-100) 0.83 (0.02-38.35) 1.01 (0.84-1.21) 17% 10 (1-32) 100 (96-100) 23.81 (1.19-478.08) 0.89 (0.76-1.04) 10% 33 (4-78) 100 (66-100) 7.14 (0.40-127.07) 0.68 (0.38-1.20) 26% 33 (12-62) 100 (89-100) 22.69 (1.34-385.54) 0.67 (0.47-0.95) 29% 0 (0-46) 100 (54-100) 1.00 (0.02-43.70) 1.00 (0.75-1.34) 19% 22 (3-60) 100 (88-100) 15.00 (0.78-286.82) 0.76 (0.53-1.09) 22% 32 (19-48) 100 (95-100) 51.56 (3.15-843.95) 0.68 (0.56-0.83) 26% 7 (0-34) 100 (91-100) 8.20 (0.35-190.49) 0.91 (0.77-1.08) 55% 57 (34-77) 100 (82-100) 22.50 (1.42-355.35) 0.45 (0.28-0.71) 62% 61 (48-73) 97 (87-100) 23.77 (3.40-166.14) 0.40 (0.29-0.55) 27% 7 (1-19) 100 (97-100) 18.98 (1.00-360.20) 0.93 (0.85-1.01) 63% 29 (10-56) 90 (55-100) 2.94 (0.40-21.73) 0.78 (0.54-1.14) 27% 6 (3-12) 100 (99-100) 35.35 (2.04-613.77) 0.94 (0.89-0.98) 26% 7 (0-34) 100 (91-100) 8.20 (0.35-190.49) 0.91 (0.77-1.08) 21% 0 (0-20) 100 (86-100) 1.39 (0.03-66.77) 0.99 (0.90-1.09) 22% 63 (44-80) 100 (97-100) 134.61 (8.36-2,166.59) 0.37 (0.24-0.59) 13% 0 (0-15) 100 (97-100) 5.22 (0.11-256.33) 0.98 (0.92-1.05) 7% 0 (0-34) 100 (94-100) 5.60 (0.12-266.27) 0.96 (0.83-1.11) 23% 70 (61-78) 96 (78-100) 16.14 (2.37-110.11) 0.31 (0.23-0.41) 20% 12 (1-36) 100 (91-100) 11.11 (0.56-219.84) 0.87 (0.72-1.05) 15% 38 (9-76) 100 (92-100) 33.44 (1.89-592.68) 0.62 (0.37-1.04) 27% 3 (0-13) 99 (95-100) 2.67 (0.17-41.60) 0.98 (0.93-1.04) 32% 52 (38-65) 87 (60-98) 3.88 (1.04-14.43) 0.56 (0.40-0.78) 9% 0 (0-98) 100 (48-100) 3.00 (0.08-107.45) 0.82 (0.35-1.89) 18% 8 (0-38) 100 (75-100) 3.23 (0.14-72.46) 0.92 (0.74-1.14) 21% 21 (5-51) 100 (79-100) 7.93 (0.45-141.43) 0.79 (0.59-1.06) 27% 20 (6-44) 100 (86-100) 11.14 (0.64-195.47) 0.80 (0.64-1.01) 28% 22 (11-37) 100 (97-100) 52.04 (3.11-869.90) 0.78 (0.66-0.91) 38% 9 (1-28) 100 (91-100) 7.92 (0.40-157.91) 0.91 (0.79-1.05) 26% 0 (0-21) 100 (92-100) 2.71 (0.06-131.06) 0.98 (0.90-1.07) 15% 52 (41-63) 67 (9-99) 1.55 (0.31-7.80) 0.72 (0.32-1.66) 16% 15 (2-45) 100 (90-100) 12.50 (0.64-244.24) 0.83 (0.65-1.07)
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