106 chapter 2 Table 4. Estimated pooled test performance of BRAF mutation analysis in indeterminate thyroid nodules ni test + test - test ? nH (%) TP FP FN TN Xing 2004 25 2 23 24 (96%) 2 0 11 11 Sapio 2007 (1) 47 1 46 20 (43%) 1 0 1 18 Sapio 2007 (2) 21 0 21 20 (95%) 0 0 2 18 Kim 2008 27 13 14 27 (100%) 13 0 8 6 Jo 2009 20 4 16 20 (100%) 4 0 2 14 Marchetti 2009 20 0 20 20 (100%) 0 0 3 17 Cantara 2010 41 2 39 41 (100%) 2 0 5 34 Moses 2010 110 3 107 110 (100%) 3 0 26 81 Adeniran 2011 (1) 84 19 65 48 (57%) 16 0 11 21 Adeniran 2011 (2) 89 12 77 25 (28%) 8 0 5 12 Kim 2011 151 46 105 50 (33%) 30 1 6 13 Nikiforov 2011 461 7 454 461 (100%) 7 0 86 368 Patel 2011 20 0 20 20 (100%) 0 0 11 9 Pelizzo 2011 119 2 117 119 (100%) 2 0 18 99 Yeo 2011 60 2 58 15 (25%) 2 0 4 9 Canadas-Garre 2012 57 5 52 47 (82%) 5 0 10 32 Kang 2012 21 0 21 12 (57%) 0 0 6 6 Mancini 2012 48 2 46 38 (79%) 2 0 7 29 Rossi 2012 200 14 186 123 (62%) 14 0 30 79 Tonacchera 2012 54 1 53 54 (100%) 1 0 13 40 Carr 2013 42 13 29 42 (100%) 13 0 10 19 Jeong 2013 103 40 63 103 (100%) 39 1 25 38 Kloos 2013 165 3 162 165 (100%) 3 0 41 121 Koh 2013 27 6 21 27 (100%) 5 1 12 9 Ohori 2013 424 7 377 40 384 (100%) 7 0 107 270 Agretti 2014 54 1 53 54 (100%) 1 0 13 40 Beaudenon-Huibregtse 2014 80 0 80 41 (51%) 0 0 17 24 Danilovic 2014 136 19 117 136 (100%) 19 0 11 106 Eszlinger 2014 (1) 164 0 141 23 141 (100%) 0 0 22 119 Eszlinger 2014 (2) 125 0 125 64 (51%) 0 0 9 55 Hyeon 2014 551 100 451 147 (27%) 87 1 37 22 Johnson 2014 86 2 76 8 56 (72%) 2 0 15 39 Liu 2014 52 3 47 2 50 (100%) 3 0 5 42 Nikiforov 2014 143 2 141 143 (100%) 1 1 38 103 Park 2014 183 54 129 73 (40%) 30 2 28 13 Poller 2014 11 0 11 6 (55%) 0 0 1 5 Seo 2014 67 1 66 25 (37%) 1 0 11 13 Borrelli 2015 68 3 65 30 (44%) 3 0 11 16 Capelli 2015 73 4 69 45 (62%) 4 0 16 25 Eszlinger 2015 163 10 148 5 158 (100%) 10 0 35 113 Gill 2015 60 2 58 60 (100%) 2 0 21 37 Giovanella 2015 61 0 61 61 (100%) 0 0 16 45 Hwang 2015 564 57 500 7 86 (15%) 43 1 40 2 Marino 2015 80 2 78 47 (59%) 2 0 11 34
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