104 chapter 2 reference country study design ntot ni included indeterminate cytology Eszlinger 2014 (2) Germany PS 154 125 follicular neoplasm or microfollicular proliferation Hyeon 2014 South Korea RS 551 551 Bethesda III Johnson 2014 UK RS 123 86 Thy3 Liu 2014 China PS 314 52 Bethesda III or IV Nikiforov 2014 USA PS+RS 143 143 Bethesda IV Park 2014 South Korea RS 331 183 Bethesda III AUS Poller 2014 UK RS 29 11 Thy3f Seo 2014 South Korea RS 485 67 Bethesda III or IV Borrelli 2015 Italy PS 650 68 TIR3 Capelli 2015 Italy RS 85 73 Thy3 Eszlinger 2015 Italy RS 347 163 Thy3 Gill 2015 Canada RS 60 60 Bethesda III or IV Giovanella 2015 Switzerland PS 61 61 Bethesda IV Hwang 2015 South Korea PS 564 564 Bethesda III Kim 2015* South Korea RS 3,297 226 Bethesda III or IV Marino 2015 Italy PS 648 80 Thy3 Le Mercier 2015 Belgium RS 34 34 indeterminate Nikiforov 2015 USA PS 465 462 Bethesda III Park 2015 South Korea PS 294 20 Bethesda III or IV Rossi 2015 Italy PS 940 118 Bethesda III or IV Beisa 2016 Lithuania n.s. 214 125 Bethesda III or IV Kowalska 2016 Poland PS 147 135 Bethesda III or IV Valderrabano 2016 USA RS 116 105 Bethesda III or IV TOTAL 22,918 6,382 *study not included in meta-analysis. AS-PCR: allele-specific PCR. AUS: atypia of undetermined significance. DPO-PCR: dual priming oligonucleotide PCR. FFPE: formalin-fixed paraffin-embedded. FLUS: follicular lesion of undetermined significance. FMCA: fluorescence melting curve analysis. f/u: follow-up. HRM: High resolution melting. MEMO: 3'-modified oligonucleotide. MGG: May-Grünwald Giemsa. ni: total number of indeterminate thyroid nodules included in our analysis. n.o.s.: not otherwise specified. n.s.: not specified. ntot: total number of thyroid nodules included in the study. PCR: polymerase chain reaction. PS: prospective. qPCR: quantitative PCR. RS: retrospective. RT-PCR: reverse transcription PCR. SHCN/HCN: cytology (suspicious for a) Hürthle cell neoplasm. SSCP: single-strand conformational polymorphism. TN: thyroid nodule. Table 3. Baseline characteristics of included studies investigating BRAF point mutations (continued)
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