100 chapter 2 Figure 4. Estimated pooled test performance of molecular and imaging biomarkers BRAF mutation RAS mutation PAX8/PPARγ rearrangement BRAF/RAS combined 7-gene GMP Afirma® GEC Galectin-3 HBME-1 Cytokeratin 19 Galectin-3/HBME-1 combined (and/orI) Galectin-3/HBME-1 combined (dualII) Qualitative elastosonography Qualitative elastosonography (score >1III) Semi-quantitative elastosonography 99mTc-MIBI scintigraphy FDG-PET(/CT) scan 3,886 6,071 2,212 3,036 1,696 2,215 2,199 3,272 1,513 1,664 958 1,665 1,016 1,044 411 419 175 175 263 263 263 263 865 865 713 713 867 867 199 199 434 434 number of studies ni 51 20 13 19 10 13 12 7 3 4 4 10 6 6 3 10 i2 i2 all (nH) best/worst case all (nH) best/worst case all (nH) best/worst case all (nH) best/worst case all (nH) best/worst case all (nH) best/worst case all (nH) best/worst case all (nH) best/worst case all (nH) best/worst case all (nH) best/worst case all (nH) best/worst case all (nH) best/worst case all (nH) best/worst case all (nH) best/worst case all (nH) best/worst case all (nH) best/worst case 0 100 50 25 75 19.7 (13.3-28.0) 20.4 (13.6-29.3) 8.8 (5.8-13.3) 27.3 (18.3-38.7) 33.6 (23.5-45.5) 14.1 (8.0-23.5) 5.9 (3.8-9.0) 6.0 (3.9-9.2) 2.4 (1.0-5.7) 48.0 (37.7-58.5) 51.1 (41.2-61.0) 26.5 (16.8-39.1) 47.4 (38.0-56.9) 51.2 (42.2-60.1) 30.1 (17.9-46.1) 97.3 (94.2-98.8) 98.2 (95.5-99.3) 42.5 (27.9-58.4) 73.9 (62.6-82.8) 75.4 (65.7-83.1) 67.7 (46.1-83.7) 80.2 (68.7-88.2) 80.9 (69.7-88.6) 76.8 (63.4-86.3) 78 (70-87)* 78 (70-87)* 78 (70-87)* 96.6 (90.8-98.8) 96.6 (90.8-98.8) 96.6 (90.8-98.8) 76.7 (62.2-86.8) 76.7 (62.2-86.8) 76.7 (62.2-86.8) 80.0 (68.5-88.0) 80.0 (68.5-88.0) 80.0 (68.5-88.0) 98.5 (91.4-99.8) 98.5 (91.4-99.8) 98.5 (91.4-99.8) 92.1 (53.6-99.2) 92.1 (53.6-99.2) 92.1 (53.6-99.2) 67 (53-82)* 67 (53-82)* 67 (53-82)* 94.2 (81.1-98.4) 94.2 (81.1-98.4) 94.2 (81.1-98.4) 91.9% 84.3% 32.5% 80.8% 68.2% 25.0% 67.8% 37.2% 0.0% 0.0% 54.0% 75.6% 94.5% n.a.c. 26.1% 27.1% sensitivity, % (95% CI) specificity, % (95% CI) 0 100 50 25 75 99.9 (99.3-100) 99.9 (99.7-100) 100 (99.8-100) 94.4 (91.5-96.3) 96.5 (94.7-97.8) 90.9 (82.6-95.5) 99.7 (98.1-100) 99.8 (98.6-100) 99.7 (97.9-100) 94.5 (91.7-96.4) 96.7 (94.6-98.0) 92.0 (84.4-96.0) 93.4 (89.4-96.0) 94.7 (91.5-96.8) 91.2 (85.3-94.9) 15.0 (9.5-22.9) 56.5 (45.4-67.0) 10.4 (6.3-16.6) 90.7 (82.7-95.2) 91.4 (83.2-95.8) 88.1 (81.3-92.6) 88.1 (81.9-92.4) 88.4 (82.3-92.6) 87.3 (80.4-92.0) 91 (81-100)* 91 (81-100)* 91 (81-100)* 78.6 (67.9-86.4) 78.6 (67.9-86.4) 78.6 (67.9-86.4) 94.3 (79.4-98.6) 94.3 (79.4-98.6) 94.3 (79.4-98.6) 81.2 (52.9-94.4) 81.2 (52.9-94.4) 81.2 (52.9-94.4) 17.6 (2.7-61.6) 17.6 (2.7-61.6) 17.6 (2.7-61.6) 93.4 (85.5-97.2) 93.4 (85.5-97.2) 93.4 (85.5-97.2) 68 (36-100)* 68 (36-100)* 68 (36-100)* 46.5 (33.5-59.9) 46.5 (33.5-59.9) 46.5 (33.5-59.9) 92.7% 75.9% 68.6% 76.8% 79.5% 92.6% 72.4% 40.3% 54.2% 53.3% 75.2% 96.5% 98.9% n.a.c. 96.2% 73.6%
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