Ann-Sophie Page

Objectives 21 The overarching aim of this project is to explore the potential benefit of three novel therapies and to optimize current surgical management options, for prolapse and/or urinary incontinence. Non-surgical treatment of prolapse and urinary incontinence Vaginal laser therapy for pelvic organ prolapse: the VELPOP-study To evaluate the efficacy and safety of vaginal Er:YAG laser application for symptomatic grade 2-3 anterior and/or posterior vaginal wall prolapse, as compared to PFE over a one year follow-up period. Vaginal laser therapy for stress urinary incontinence: the VELSUI-study To evaluate the efficacy and safety of vaginal Er:YAG laser application for mild to moderate SUI, as compared to PFE over a one year follow-up period. Surgical treatment of prolapse and urinary incontinence Cervicosacropexy or vaginosacropexy for urinary incontinence and apical prolapse: A systematic review To systematically review and summarize the evidence on the efficacy and safety of cervicosacropexy and vaginosacropexy as alternative surgical treatment options for urge and/or mixed urinary incontinence and apical prolapse, in view of potential addition to our portfolio. Evaluation and optimization of sacrocolpopexy as surgical treatment for apical prolapse • Long-term Data on Graft-Related Complications After Sacrocolpopexy With Lightweight Compared With Heavier-Weight Mesh To estimate the long-term incidence and characteristics of GRC, rate of reinterventions for GRC and prolapse, subjective and anatomical outcomes after laparoscopic sacrocolpopexy with heavier-weight (over 44 g/m²) compared to lightweight (28 g/m²) polypropylene mesh, the latter with a resorbable poliglecaprone component. • Safety and medium-term outcome of redo laparoscopic sacrocolpopexy: a matched case–control study To document the functional and anatomical outcomes of redo laparoscopic sacrocolpopexy procedures on the medium-term, when compared to primary procedures. • Cost of using glue rather than sutures for mesh fixation during sacrocolpopexy To perform a cost minimization study when replacing (part of the) sutures by a synthetic glue for mesh fixation. • An automated workflow analysis to evaluate novel modifications and learning curves in sacrocolpopexy Surgical workflow analysis is an important component to standardize the timeline of a procedure and for later training purposes. Automating this task would greatly assist in the

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