25 Systematic review Table 1: [continued] Study Author, year, country Design N operated VWD; (type VWD) Follow-up (months) Primary Outcome(s) Perioperative prophylaxis Bleeding complications - VWD% (N bleeding /N total) - Control%) Polet et al, 1996, South-Africa12 Case report 1 (NR) NR Physician reported bleeding complications None Vaginal vault bleeding - VWD 100% (1/1) - Control 0%) Alesci S et al, 2012, Germany20 Retrospective cohort 12 (type 1, type 2A, type 2N, acquired) NR Physician reported bleeding complications VWF/FVIII concentrate None occurred Halimeh S et al, 2012, Germany18 Retrospective cohort 7 (type 1, type 3) NR Physician reported bleeding complications TA None occurred Endometrial ablation Kanaoka et al, 2001, Japan17 Retrospective cohort 1 (type 1) 15 (12-18) months Physician reported bleeding complications, satisfaction (questionnaire not specified) Buserelin nasal spray None occurred Rubin et al, 2004, USA14 Retrospective cohort 7 (type 1, type 2) 45 (31-73) months Physician reported bleeding complications, satisfaction (questionnaire not specified) DDAVP (type 1); VWF/FVIII (type 2A) None occurred El-Nashar et al, 2007, USA16 Retrospective cohort 2 (type 1) 24 (11-39) months Physician reported bleeding complications Received but type not specified None occurred [continued on next page] 2
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