24 Chapter 2 Table 1: Study characteristics, adverse events and bleeding complications in endometrial ablation or hysterectomy (N=12). Study Author, year, country Design N operated VWD; (type VWD) Follow-up (months) Primary Outcome(s) Perioperative prophylaxis Bleeding complications - VWD% (N bleeding /N total) - Control%) Hysterectomy de Wee et al, 2011, Netherlands3 Retrospective cohort 84 (type 1, type 2, type 3) NR Self-reported complications NR Self-reported intra/ postoperative bleeding - VWD: 58% (29/50 data available surgeryrelated bleeding) - Control: NR Ragni et al, 1999, USA22 Retrospective cohort 7 (type 1) NR Physician reported bleeding complications NR Postoperative bleeding - VWD: 28.6% (2/7) - Control: NR James et al, 2009, USA19 Retrospective cohort 545 (NR) NR Physician reported bleeding complications NR Intra/ postoperative bleeding - VWD 2.8% (15/545) - Control 0.9% (12218/1357588); Death - VWD 0.2% (1/545) - Control 0.1% (1764/1357588) Transfusion - VWD 7.3% (40/545) - Control 2.1% (28509/1357588) Kadir et al, 1999, United Kingdom21 Retrospective cohort 5 (type 1, type 2, type 3) NR Physician reported bleeding complications DDAVP VWF/FVIII concentrate Vault hematoma - VWD 20% (1/5) - Control NR) Wound hematoma - VWD 20% (1/5) - Control NR) Hematuria/ postoperative bleeding - VWD 20% (1/5) - Control NR [continued on next page]
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