69 The incidence of different forms of ileus following surgery for abdominal birth defects in infants Chapter 3 Anastomotic Stenosis Of the 14 studies reporting on anastomotic stenosis within one month of follow-up, 365 patients were included and 22 events of anastomotic stenosis occurred [41, 49, 51, 64, 83, 97, 134, 140, 147, 238, 240, 248, 268, 300]. The pooled proportion of total anastomotic stenosis within a month was 0.03 (95%-CI: 0.01-0.10; I2 = 81%, p = 0.02). Diseases reported on were: small intestinal atresia (n=8/163), Hirschsprung’s disease (n=10/60), duodenal obstruction (n=2/56), anorectal malformations (n=0/30), choledochal cyst (n=0/30) and colonic atresia (n=2/26). In total, 40 studies reported on anastomotic stenosis after one month of followup entailing 4468 patients and 214 events of anastomotic stenosis occurred [49, 56, 62, 64, 68, 87, 92, 97, 101, 108, 109, 123, 130, 133, 141, 147, 149, 152, 153, 161, 206, 213, 214, 219-221, 223, 224, 230, 236, 241, 245, 247, 248, 252, 260, 264, 266, 268, 270, 272, 274, 275, 277, 279, 285, 286, 304-306, 308]. Length of follow up was at least half a year in 29 (73%) of the studies. the pooled proportion of anastomotic stenosis was 0.04 (95%- CI: 0.03-0.06; I2 = 59%, p = 0.30). Separate proportions were calculated for the following conditions: Hirschsprung’s disease 0.04 (95%-CI: 0.03-0.07; n=162/3238; I2 = 70%; p = 0.11); small intestinal atresia 0.06 (95%-CI: 0.04-0.08; n=32/548; I2 = 0%; p = 0.77); duodenal obstruction 0.02 (95%-CI: 0.01-0.04; n=11/547; I2 = 42%; p = 0.29); gastroschisis 0.08 (95%- CI: 0.04-0.14; n=9/118; I2 = 0%; p = 0.77). Colonic atresia (N=17) is included in the overall proportion but did not meet the criteria for separate statistical analysis (Figure 4). Figure 4 – Pooled proportion of anastomotic stenosis after 1 month
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