Laurens Schattenkerk

47 The incidence of abdominal surgical site infections after abdominal birth defects surgery in infants Chapter 2 Separate pooled proportions were calculated for the following conditions: Hirschsprung’s disease 0.02 (95% CI: 0.01-0.04; n = 117/3413; I2 = 72%; p = 0.09); Duodenal obstruction 0.01 (95% CI: 0.00-0.04; n = 15/888; I2 = 64%; p = 0.01); Small intestinal atresia 0.07 (95% CI: 0.05-0.09; n = 41/630; I2 = 0%; p = 0.84); Colonic atresia 0.14 (95% CI: 0.06-0.27, n = 6/44; I2 = 0%; p = 0.85). Meconium ileus (N=34) was included in the overall proportion but did not meet the criteria for separate statistical analysis. Figure 4 - Pooled proportions anastomotic leakage Post-operative peritonitis Post-operative peritonitis was reported in eight studies, reporting on a total of 310 patients of whom twelve suffered from post-operative peritonitis. The pooled proportion of total post-operative peritonitis was 0.03 (95%-CI: 0.01 – 0.09; I2 = 53%, p = 0.16) [38, 66, 70, 71, 83, 98, 125, 132]. Since the total amount of post-operative peritonitis was under 50, no separate pooled proportions were calculated for the included anomalies. The included anomalies are: gastroschisis (N=5/171), biliary atresia (N=2/72), congenital diaphragmatic hernia (N=1/30) and Hirschsprung’s disease (N=4/37). Fistula development Fistula development was reported in seven studies reporting a total of seven fistulas in 331 patients. Of the seven patients one entero-enteric fistula and six enterocutaneous fistulas were reported. The pooled proportion of total fistula development was 0.02 (95%-CI: 0.01 – 0.04; I2 = 0%, p = 0.57) [35, 36, 96, 99, 120, 143, 158] . Since the total amount of fistula development

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