Laurens Schattenkerk

45 The incidence of abdominal surgical site infections after abdominal birth defects surgery in infants Chapter 2 Wound infection Wound infection was described in 108 studies. In 8396 patients, 585 wound infections were seen. The pooled proportion of total wound infection was 0.06 (95%-CI: 0.05 – 0.07; I2 = 81%, p ≤ 0.01) (Figure 2). [35, 37-39, 41-46, 48, 50, 52-55, 57-62, 65, 67, 71, 72, 74-78, 81-86, 89, 94-104, 106, 108, 110-115, 120-126, 128-130, 133, 135-138, 140, 144-148, 150-152, 155-159, 161-168, 171, 172, 174-184, 186, 187] Separate pooled proportions were calculated for the following conditions: Gastroschisis 0.10 (95% CI: 0.06-0.15; n = 262/2468; I2 = 91%; p ≤ 0.01); Hirschsprung’s disease 0.07 (95% CI: 0.05-0.10; n = 130/2421; I2 = 67%; p ≤ 0.01); Anorectal malformations 0.05 (95% CI: 0.03-0.08; n = 88/1389; I2 = 67%; p = 0.01); Duodenal obstruction 0.05 (95% CI: 0.03-0.09; n = 29/620; I2 = 59%; p ≤ 0.01); Biliary atresia 0.03 (95% CI: 0.01-0.07; n = 13/488; I2 = 59%; p = 0.39); Small intestinal atresia 0.07 (95% CI: 0.04-0.12; n = 21/304; I2 = 30%; p = 0.21); Diaphragmatic hernia 0.04 (95% CI: 0.02-0.10; n = 14/259; I2 = 44%; p = 0.58); Choledochal cyst 0.01 (95% CI: 0.00-0.05; n = 1/151; I2 = 0%; p = 1.00); Omphalocele 0.12 (95% CI: 0.05-0.27; n = 21/140; I2 = 69%; p = 0.29). Meckel diverticula (N=46), meconium ileus (N=44), teratoma (N=42), malrotation (N=33) and duplication cyst (N=1) are included in the overall proportion but did not meet the criteria for separate statistical analysis. Figure 2 - Pooled proportions wound infection

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