309 English summary Appendices Moreover, based on our results, we are now more likely to prefer a tunneled catheter over a non-tunneled one if patients are treated with an enterostomy or if a longer duration of TPV treatment is deemed likely. Secondly, we evaluated the complication incisional hernia. We reported an incidence of 5% in our cohort, which increased to 7% when excluding patients with a follow-up of less than a year. These results are comparatively higher than cohorts that include children of all ages, mostly including patients from zero to 16 or 18 years. We suspect that this difference is caused by the types of diseases young children are treated for, which we believe are more at risk of incisional hernia development. This is also reflected in the risk factors we identified for incisional hernia namely a history of prematurity, treatment by enterostomy and wound infections. Interestingly, one in seven of these hernias resolved by itself, without the need for redo surgery. Thirdly we set-out to evaluate adhesive small bowel obstruction. We reported an overall incidence of adhesive obstruction of 5%. Following laparoscopic treatment 1% too developed this complication. Most of these SBOs occurred within the first half year of follow-up. Having undergone treatment with an enterostomy was again an independent risk factor. Lastly, we analysed the complications anastomotic leakage and stenosis following primary anastomosis. Our reported incidence of anastomotic stenosis was 7% and leakage occurred in 5%. Out of all technical factors, only colonic anastomosis seemed significantly associated to stenosis compared to small bowel anastomosis. Anastomotic leakage occurred significantly more often in patients with an ASAS score of III or higher and in male patients. Mortality due to anastomotic complications occurred in less than one percent. Based on these results, we believe that anastomotic complications are relatively rare and treatable. These conclusions support choosing primary anastomosis over enterostomy in case of uncertainty about the best treatment. Using patient-specific risk factors for leakage might, in the future, help decide between these options. Part IV - Complications of- and enterostomy related morbidity In this part we evaluated the effect of treatment by enterostomy in our own cohort of patients. First, we wanted to get an overview of the enterostomy related morbidity following enterostomy formation and closure. Taking into account both formation and closure, 39% of the patients experienced a Clavien-Dindo Grade III or higher complication. Those treated by ileostomy were independently more at risk of developing complications both following
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