227 Major stoma related morbidity in young children following stoma formation and closure Chapter 10 inflammatory disease (necrotizing enterocolitis and meconium peritonitis patients), vasopressin usage post-surgery, history of prematurity (defined as gestational age < 37 weeks), weight at surgery, location of the stoma (ileostomy, jejunostomy or colostomy), duration of presence of a stoma in days and suture resorption speed (defined as normal (Vicryl©, Novosyn©, Monocryl©) or slow (PDS and Monosyn plus©)) used for fascial suturing. These factors were chosen based on previous literature as well as clinical significance aiming to identify general, rather than disease specific, risk factors. Statistical analysis Descriptive data were reported as median with interquartile range. Comparison between treatment groups were performed using chi-square test for categorical data, and the Mann-Whitney U test for non-parametric continuous data. Chi squared testing was used to analyse if overall major stoma related morbidity differed over the years comparing patients operated within a consecutive five-year period starting from 1998. Multivariable logistic regression analysis was performed separately for both stoma formation and closure in order to identify risk factors for morbidity. The assumption of linearity of the logit of ordinal variables was assessed using the Box-Tidwell test. Backward Wald selection was used for selection of variables and assessment of confounding (increase in B-coefficient of >10%) and effect modification (significant interaction term). Significant risk factors were reported in odds ratio (OR) with 95% confidence intervals (95%-CI). Additionally, the adjusted R-squared is reported to show the proportion of the variance in the occurrence of major morbidity explained by the model. Results Patient and stoma characteristics are displayed in Table 1. In total, 336 young children were included of which 35% (n=118/336) were treated for an underlying inflammatory disease (necrotizing enterocolitis and meconium peritonitis). Of all patients, 61% (n=205/336) was male. The median birthweight was 2640 grams and the median gestational age was 36 weeks. Of all patients, 41% (n=137/336) was born prematurely. The type of stoma was a jejunostomy in 5% (n=17/336), ileostomy in 57% (n=192/336), and colostomy in 38% (n=127/336). Mortality at the end of follow-up was 15% (n=49/336). Major stoma related morbidity occurred in 15% (n=49/336) of patients within 30 days following formation (Table 2). The most common morbidity was high output (6%, n=19/336), stoma necrosis (3%, n=9/336) and stoma prolapse (2%, n=8/336). Death within 30 days to non-stoma related causes occurred in 9% (n=29/336), leaving 307 patients to be assessed for complications risk after 30 days. Following 30 days, a major complication occurred in 19% of patients (n=58/307). Most reported were high output (6%, n=19/307),
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