Laurens Schattenkerk

193 Adhesive small bowel obstruction following abdominal surgery in young children (≤ 3 years) Chapter 8 have a history of stoma. This suggested that, compared to one operation, those who underwent two procedures (HR: 3.7, 95%-CI: 1.2 – 10.8) and three or more procedures (HR:3.4, 95%-CI: 1.1 – 10.4) had significant higher hazard of SBO occurrence. There was no difference between two procedures and three or more procedures (p = 0.839). Due to the possibility of informative censoring in the cox regression caused by the short term follow-up of laparoscopically treated patients (median 75 days, range 0-6366) another sensitivity analysis was performed by means of a logistic regression on the outcome of SBO with surgical approach as control variable. . This indicated that the risk of SBO development following laparotomies is higher than laparoscopies (OR: 4.3, 95%-CI: 1.7-10.6). Table 1 - Patient characteristics Variable Total operated (N = 2055) Patients with SBO (N=88) Count (%) (missing) Count (%) (missing) Male 1352 (66%) 51 (58%) Preterm birth 565 (28%) (missing: 420) 46 (52%) (missing: 9) Surgery for birth defect1 1032 (50%) 59 (67%) Median age in days (range)1 47 (0 – 1095) 11 (0 - 678) Median weight in grams (range)1 3885 (515 – 17200) (missing: 1029) 2725 (870 – 8800) ( missing:49) Emergency procedure1 1055 (51%) 62 (71%) Laparotomy1 1616 (79%) (missing:28) 73 (94%) Intestinal resection1 623 (30%) (missing:28) 36 (41%) Anastomosis created1 497 (24%) (missing: 28) 24 (27%) ( missing: 5) Mean hours duration of surgery (std) 1.4 (1.0) (missing: 366) 1.9 (1.0) (missing: 20) Postoperative infection Yes Superficial 133 (8%) 7 (9%) Deep 34 (2%) 2 (3%) Line infection 133 (8%) 11 (13%) Missing origin 162 (10%) 14 (17%) No No infection 1142 (72%) (missing: 451) 48 (58%) (missing: 6) Had a history of stoma 429 (21%) 44 (50%) Median abdominal procedures (range) 1 (1-13) 2 (1-11) Median of follow-up (range) (0 – 286) 52 (1 – 271) Died since primary operation 127 (6%) ( missing:10) 10 (11%) *1 at/following primary surgery

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