Laurens Schattenkerk

159 Central venous catheter associated bloodstream infections and thrombosis in patients treated for gastroschisis and intestinal atresia Chapter 6 A catheter related thrombosis occurred significantly more often in non-tunnelled central venous catheters (p = 0.03). Occurrence of thrombosis was not correlated with either peripheral insertion or direct insertion into a central vein of the catheter (p = 0.34). Table 2 – Classification of the intestinal atresias Intestinal Atresia (N=175) Complex gastroschisis (N=14) Location of the atresia Pylorus 2 (1%) 0 Duodenum 98 (56%) 0 Jejunum 32 (18%) 2 (14%) Ileum 29 (17%) 9 (64%) Colon 7 (4%) 0 Multiple locations 7 (4%) 3 (21%) Type of jejunoileal atresia Type 0 6 (9%) 0 Type I 17 (25%) 2 (14%) Type II 16 (24%) 1 (7%) Type III-A 13 (19%) 1 (7%) Type III-B 4 (6%) 7 (50%) Type IV 11 (16%) 3 (22%) Unclear 1 (1%) 0 Table 3 – Complications associated with the first inserted central venous catheter Total number of patients included (N= 238) Intestinal atresia (N = 175) Gastroschisis (N = 63) Complication directly associated to placement Incision other side neck necessary 3 (2%) 3 (5%) Post-operative catheter tip readjustment necessary 10 (6%) 13 (21%) Pneumothorax 0 0 Enterostomy during central venous catheter 36 (21%) 6 (30%) Median time from admission until insertion (IQR) 2 days (1 – 4) 0 days (0 – 1) Place of insertion Internal Jugular 43 (24%) 29 (46%) External Jugular 61 (35%) 14 (22%) Subclavian 15 (9%) 7 (11%) Femoral 3 (2%) 1 (2%) Superior limbs 13 (7%) 5 (8%) Saphenous magna 32 (18%) 3 (5%) Inferior limbs 8 (5%) 4 (6%) Central venous catheter centrally inserted 122 (70%) 38 (81%) Central venous catheter tunnelled 133 (76%) 41 (65%)

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