129 Incisional hernia after surgical correction of abdominal congenital anomalies in infants Chapter 5 Data extraction Titles and abstracts were screened by two independent authors (LES, DN) using Rayyan. Rayyan is an online based software that facilitates blind collaboration among reviewers. Disagreements were resolved by discussion between the two review authors. A third specialist author (JD or GM) was consulted if consensus was not reached. Afterwards the full text of the remaining articles was read to determine eligibility for inclusion (LES, DN). If the full text was not found the authors were contacted. Of the included articles the reference list was cross-checked to find any additional articles. Validity and Eligibility assessment All included articles were assessed for the methodological quality and risk of bias using the Newcastle Ottawa quality assessment scale [32]. LES and DN did the assessment separately. Data synthesis For each study, a weighted average of the logit proportions of IH was determined by the use of the generic inverse variance method. The logit proportions were back transformed to the summary estimate and 95% CIs were obtained in a summary proportion representing the pooled proportion of the IH. Heterogeneity was assessed using the I2 and χ2 statistics. Analysis was performed using R-studio version 3.6.1 (package “meta” (Schwarzer, 2007) and “metaprop” (Viachtbauer, 2010)). The random-effects model was used for interpretation. Heterogeneity was deemed significant if the pooled data’s p value was <0.05 or χ2 statistics were ≥75. Heterogeneity was interpreted as small (I2≤0.25), medium (I2=0.25 – 0.50) or strong (I2≥0.50), according to Higgins [34]. The gastroschisis subgroup analysis were performed using review manager (version 5.3) to generate forest plots. In this part of the meta-analysis the odds ratio was calculated using MantelHaenszel statistics, using the random-effects model to interpret results. Results Study characteristics During the search 5794 records were identified. Automated removal of duplicates left 3909 records for title and abstract screening. Of these 3909 records, 722 met the criteria for full text assessment. One article was included after screening references of included articles. Full text evaluation resulted in 50 studies, which were included for quantitative analysis (Figure 1). These 50 studies represent 3140 patients (Table 1). Risk of bias was assessed and is shown in Table 2, most of the included studies reported fair quality on the NOS.
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