Pregnancy intention in relation to maternal and neonatal outcomes in women with vs without psychiatric diagnoses 91 Association between unintended pregnancies and adverse maternal and neonatal outcomes In Supplementary Table S4.1 we present demographic features of all four study groups in the secondary analyses (UP yes/no and current/past psychiatric diagnosis (yes/no). Table 4.3 displays the estimated associations of UPs on maternal and neonatal outcomes in two models: model 1 including main effects for UPs and current/past psychiatric diagnosis and model 2 including an interaction for both variables. There was no association between UPs and maternal outcomes (gestational diabetes mellitus, hypertensive disorders of pregnancy, assisted vaginal delivery and cesarean section). In addition, there was no interaction effect of UPs and current/past psychiatric diagnoses maternal outcomes. Neonatal outcomes were comparable between women with UPs and with intended pregnancies. Except from GA at delivery, current/past psychiatric diagnoses did not modify neonatal outcomes in women with UPs. After addition of the interaction term (model 2), women with UPs had a 2.63 days lower mean GA at delivery than women in the reference group (p=0.096), women with current/ past psychiatric diagnoses had 1.67 days lower mean GA at delivery than women in the reference group (p=0.204), but women with both UPs and current/past psychiatric diagnosis had a 2.21 days higher mean GA at delivery than women in the reference group (p-value interaction = 0.001). All other neonatal outcomes were comparable for UPs versus intended pregnancies, and there were no interaction effects. Post hoc sensitivity analyses To comprehend the interaction effect of psychiatric diagnosis on the association between pregnancy intention and GA age at delivery, we performed a post hoc sensitivity analysis focusing on the two largest groups of DSM classified diagnoses; women with a current/past depressive disorder (N=704) and women with a current/past anxiety disorder (n=399). We compared GA at delivery in these two groups of women versus women without any current/past psychiatric diagnosis (n = 1093). Current/ past depressive disorders modified the association between UPs and mean GA (p-value interaction =0.003). Current/past anxiety disorders did not modify the association between UPs and GA at delivery (p-value interaction = 0.068).
RkJQdWJsaXNoZXIy MTk4NDMw