Chapter 4 86 percentages. Differences in demographics between women with intended pregnancies and UPs were described using T-tests or Chi-square tests. For the primary aim, the number of UPs was compared between women with and without current/past psychiatric diagnosis using logistic regression analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated. Subsequently, we performed logistic regression analyses with a dummy variable for having any current/past psychiatric diagnosis to assess the association of various psychiatric diagnosis with pregnancy intention. All models were adjusted for parity, employment status, psychotropic medication use, age, and ethnicity. For the secondary aim, we compared maternal and neonatal outcomes between women with UPs versus non-UPs. Generalized linear models were fitted, depending on the nature of the outcome variable: linear regression models for continuous outcomes and logistic regression models for dichotomous outcomes. All models included a main effect for UP (yes/no) and were adjusted for parity, employment status, age, alcohol use, smoking, and psychotropic medication use. To evaluate a differential effect of psychiatric diagnosis on the association between UP and maternal and neonatal outcomes, each model was extended with a main effect current/past psychiatric diagnosis (yes/no), and an interaction term for UP with current/past psychiatric diagnosis. Main effects and interaction effects were presented as mean difference (MD) or OR with 95% CI. Wald p-values were estimated for all effect sizes, except the interaction term with psychiatric diagnosis, for which we used a Likelihood Ratio Test to assess the added value of the interaction term. P-values of <0.05 were considered statistically significant. Ethical considerations The study protocol was approved by the Medical Research Ethics Committees United and the Advisory Committee Scientific Research at OLVG. The study was granted exempt from the Human Subjects Act, as declared by the Medical Research Ethics Committees United and exempt from informed consent procedures given the numbers of inclusion and mostly coded data collection. If patients indicated not to be willing to participate in any chart research (as noted in their medical chart), their data were not included in the study.
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