47 Study Characteristics Study Results Study CKD-pop(N) Country Design Measure (% LHL) Q Mechanism(s) Association of health literacy with mediator within this mechanism(s) or other result related to mechanism Association of health literacy or mediator with health outcome? Wong et al. 2017(64) 4-5 (121) Canada Crosssectional SLS1 (n.a.) - Utilization of care Yes: LHL with requiring help to fill in measurements with tablets, and finding this task difficult or tiring. No results reported on health outcomes. Flythe et al. 2017(67) 4-5 (154) USA Crosssectional REALM1 (43.3%) - Utilization of care Yes: LHL shows a trend towards higher likelihood of 30-day hospital readmission (non-significant in adjusted models). No results reported on health outcomes. Tohme et al., 2017(42) 5(D) (286) USA Mixedmethods REALM1 -16% - Utilization of care Yes: LHL with missing dialysis, No: LHL with patients’ abbreviation of dialysis treatment. Missing dialysis with mortality. Abbreviation with hospitalization. Grubbs et al., 2009(35) 5(D) (62) USA Crosssectional sTOFHLA1 (32.3%) - Utilization of care Yes: LHL with lower referral change for transplant evaluation. No: LHL with treatment preference, uncertainties about treatment decision or being waitlisted. No results reported on health outcomes. Studies with results on mechanisms related to patient-provider interaction (N=1) Bahadori et al., 2018(69) 5(D) (130) Iran Crosssectional HELIA1,2,3 (53.8%) - P-P interaction Yes: Various subdomains of LHL (understanding and using information, decision making) with perceived general health. Yes: LHL with physical and psychological symptoms. CKD-pop = population of interest by CKD-stage (1,2,3,4 or 5), when applicable specified for transplant (T) or dialysis (D). N= number of participants in study 1 = functional HL measure, 2 = communicative HL measure, 3 = critical HL measure Q = study quality: + high quality study, +/- moderate quality study and - low quality study, based on quality assessment. Table 2.1 Continued
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