Marco Boonstra

196 Table 6.1. Input parameters used in the Markov model Parameter Value 95% CI Distribution Source Mortality Incident mortality CKD 1/2 Age-dependent 0.01 to 0.39* beta 21 Incident mortality CKD 3/4 Age-dependent 0.03 to 0.70* beta 22 Incident mortality ESRD Age-dependent 0.11 to 1.00* beta 21,23 Annual transition probabilities CKD 1/2 to CKD 3/4 0.10 0.04 to 0.12* beta 25-27 CKD 3/4 to ESRD 0.09 0.03 to 0.17* beta 27,28 Quality of life (utilities) CKD 1/2 0.93 0.81 to 1.00 beta 29 CKD 3/4 0.80 0.68 to 0.98 beta Derived ESRD 0.56 0.49 to 0.62 beta 30 Intervention effect (relative risk) Transition CKD 1/2 to CKD 3/4 0.81 0.71 to 0.92 normal Association GoYK and hypertension: derived Association hypertension and CKD: 31 Transition CKD 3/4 to ESRD 0.73 0.65 to 0.82 normal Association GoYK and hypertension: derived Association hypertension and ESRD: 32 Annual costs (euros) Direct medical costs CKD 1/2 1,844 1,475 to 2,213 gamma Prevalence: 21,26,33,34 Costs: 35 CKD 3/4 2,394 1,915 to 2,873 gamma Prevalence: derived Costs: 35 ESRD 98,221 54,666 to 141,775 gamma Costs: 5 Indirect medical costs Last year of life age- and sex-dependent 43,353 to 54,770 gamma 36 Other years of life age- and sex-dependent 5,415 to 38,829 gamma 36 CKD: chronic kidney disease; ESRD: end-stage renal disease; CI: confidence interval; Derived: obtained from the data of the GoYK study; *Total range reported in place of 95%CI

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