192 ABSTRACT Background Chronic kidney disease (CKD) is a progressive disease with high societal costs. CKD progression is influenced by patients’ health literacy, i.e., the patients’ ability to deal with information related to their own health. Grip on Your Kidneys (GoYK), a multi-component health literacy intervention for CKD patients and healthcare professionals, might be a solution to slow CKD progression and, thereby, reduce CKD costs. Methods We used a Markov model to evaluate the effects of GoYK on quality-adjusted life years (QALYs) and healthcare costs in the Netherlands, compared to care-asusual. Results We found that the GoYK intervention would yield a cost-saving of €28,616 and a gain of 0.37 QALYs per CKD patient across the life course. Moreover, GoYK would avert 31 deaths and 113 new dialyses per 1,000 patients in the first 10 years. These results mainly stemmed from the intervention effect on the transition to endstage renal disease, where reductions of as little as 1% would already mean GoYK is cost-saving. The intervention remained cost-effective in multiple sensitivity and scenario analyses. Discussion We recommend the implementation of GoYK by healthcare organizations and its incorporation into health guidelines and reimbursement plans. Given the novelty of our study, the implementation of GoYK should be combined with further research on its long-term effects and subgroups that could benefit the most from it.
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