184 133 Supplementary file 4 Analyses for patients who used two or more intervention components, for the imputed dataset Linear and logistic regressions of primary outcomes for the change between T0-T1 and T0-T2, with imputation and correction for eGFR. Continuous primary outcomes Group Baseline T1 T2 Intervention effect T0-T1 Intervention effect T0-T2 B (95% CI) p B (95% CI) p PAM1 mean (SD) CAU 55.6 (10.0) 56.3 (14.2) 59.0 (13.1) 1.48 (-3.50 to 6.46) 0.560 -4.58 (-8.99 to -0.17) 0.042 IG 62.1 (12.8) 64.8 (15.2) 62.3 (11.1) Medication adherence2 mean (SD) CAU 23.8 (2.0) 23.7 (2.5) 23.6 (2.1) 0.12 (-0.70 to 0.94) 0.773 0.21 (-0.64 to 1.06) 0.626 IG 23.4 (2.3) 23.4 (2.4) 23.5 (2.3) Alcohol (doses per week) mean (SD) CAU 6.4 (5.5) 5.7 (5.0) 6.3 (6.3) 0.14 (-1.43 to 1.71) 0.863 -1.20 (-3.07 to 0.67) 0.207 IG 4.3 (6.4) 3.8 (4.4) 3.3 (4.5) Salt intake (days per week) mean (SD) CAU 5.1 (1.9) 4.8 (2.1) 5.1 (2.1) -0.16 (-0.75 to 0.43) 0.592 -0.71 (-1.41 to -0.01) 0.047 IG 5.1 (1.8) 4.5 (1.9) 4.4 (1.9) Dichotomous primary outcomes Group Baseline T1 T2 OR (95% CI) p OR (95% CI) p Adequate physical activity3 % CAU 44.1 37.5 42.4 1.75 (0.68 to 4.48) 0.245 0.91 (0.39 to 2.13) 0.830 IG 37.5 41.4 34.8 Drink more than 1.5L a day % CAU 62.8 60.9 66.8 1.57 (0.65 to 1.57) 0.319 0.81 (0.34 to 1.95) 0.638 IG 49.9 61.1 54.0 Statistics based on the imputed dataset, but only participants who used ≥2 components of the intervention were included in the analysis. Numbers in bold indicate significant results. n of alcohol is 75 (only people who drank were analysed); all other n = 129. B = parameter estimate of being in the IG for the difference T1-T0 or T2-T0, CI = confidence interval, SD = standard deviation, CAU = care-as-usual, IG = intervention group, OR = odds ratio for improvement in the IG compared to CAU between baseline and T1 or T2. 1 Patient Activation Measure: scores from 0 to 100 with higher scores representing better patient activation. 2 Medication adherence: scores from 5 to 25 with higher scores representing better adherence. 3 Adequate physical activity: at least 150 minutes of exercise per week. Supplementary file 4: Analyses for patients who used two or more intervention components, for the imputed dataset
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