Marco Boonstra

181 130 Supplementary file 2 Analyses without correction for eGFR for the imputed dataset Linear and logistic regressions of primary outcomes for the change between T0-T1 and T0-T2, with imputation and without correction for eGFR. Continuous primary outcomes Group Baseline T1 T2 Intervention effect T0-T1 Intervention effect T0-T2 B (95% CI) p B (95% CI) p PAM1 mean (SD) CAU 55.6 (10.0) 56.3 (14.2) 59.0 (13.1) 0.76 (-4.84 to 6.37) 0.789 -2.63 (-6.91 to 1.64) 0.227 IG 61.7 (13.6) 63.1 (17.5) 62.5 (11.4) Medication adherence2 mean (SD) CAU 23.8 (2.0) 23.7 (2.5) 23.6 (2.1) -0.15 (-1.15 to 0.85) 0.770 0.01 (-0.93 to 0.94) 0.988 IG 23.4 (2.2) 23.2 (2.9) 23.2 (2.6) Alcohol (doses per week) mean (SD) CAU 6.4 (5.5) 5.7 (5.0) 6.3 (6.3) 0.27 (-1.15 to 1.69) 0.710 -0.83 (-2.58 to 0.92) 0.352 IG 4.6 (6.5) 4.2 (5.1) 3.7 (5.1) Salt intake (days per week) mean (SD) CAU 5.1 (1.9) 4.8 (2.1) 5.1 (2.1) -0.04 (-0.67 to 0.60) 0.910 -0.53 (-1.25 to 0.20) 0.152 IG 4.9 (1.9) 4.5 (2.0) 4.4 (2.0) Dichotomous primary outcomes Group Baseline T1 T2 OR (95% CI) p OR (95% CI) p Adequate physical activity3 % CAU 44.1 37.5 42.4 1.82 (0.76 to 4.36) 0.178 0.87 (0.40 to 1.87) 0.719 IG 34.6 42.1 35.7 Drink more than 1.5L a day % CAU 62.8 60.9 66.8 1.22 (0.56 to 2.66) 0.622 0.77 (0.34 to 1.73) 0.052 IG 48.0 58.3 56.4 Statistics based on the imputed dataset. n of alcohol is 84 (only people who drank were analysed), all other n = 147. B = parameter estimate of being in the IG for the difference T1-T0 or T2-T0, CI = confidence interval, SD = standard deviation, CAU = care-as-usual, IG = intervention group, OR = odds ratio for improvement in the IG compared to CAU between baseline and T1 or T2. 1 Patient Activation Measure: scores from 0 to 100 with higher scores representing better patient activation. 2 Medication adherence: scores from 5 to 25 with higher scores representing better adherence. 3 Adequate physical activity: at least 150 minutes of exercise per week. Supplementary file 2: Analyses without correction for eGFR for the imputed dataset

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