Marco Boonstra

179 SUPPLEMENTARY FILES 128 Supplementary files Supplementary file 1: Crude analyses Linear and logistic regressions of primary outcomes for the change between T0-T1 and T0-T2, without imputation and without correction for eGFR. Continuous primary outcomes Group Baseline T1 T2 Intervention effect T0-T1 Intervention effect T0-T2 B (95% CI) p n B (95% CI) p n PAM1 mean (SD) CAU 55.7 (10.0) 56.5 (12.8) 58.8 (14.0) 1.65 (-2.06 to 5.37) 0.380 125 -2.25 (-6.64 to 2.13) 0.311 121 IG 61.3 (13.3) 63.7 (15.3) 62.8 (12.5) Medication adherence2 mean (SD) CAU 23.7 (2.0) 23.9 (2.1) 23.8 (1.7) 0.19 (-0.29 to 0.68) 0.429 134 0.35 (-0.24 to 0.95) 0.240 127 IG 23.4 (2.2) 23.5 (2.2) 23.6 (2.0) Alcohol (doses per week) mean (SD) CAU 6.3 (5.6) 5.7 (5.0) 6.3 (6.4) 0.27 (-1.15 to 1.69) 0.705 84 -0.81 (-2.57 to 0.94) 0.358 84 IG 4.7 (6.7) 4.3 (5.2) 3.8 (5.2) Salt intake (days per week) mean (SD) CAU 5.1 (1.9) 4.8 (2.1) 5.2 (2.0) -0.18 (-0.71 to 0.35) 0.507 135 -0.48 (-1.02 to 0.06) 0.079 127 IG 4.9 (2.0) 4.6 (1.9) 4.5 (1.9) Dichotomous primary outcomes Group Baseline T1 T2 OR (95% CI) p n OR (95% CI) p n Adequate physical activity3 % CAU 43.9 38.1 43.1 2.04 (0.84 to 4.96) 0.114 133 0.93 (0.41 to 2.13) 0.865 125 IG 33.8 43.7 35.3 Drink more than 1.5L a day % CAU 63.1 60.9 67.2 1.30 (0.58 to 2.89) 0.529 133 0.70 (0.31 to 1.55) 0.375 124 IG 47.5 59.2 54.4 B = parameter estimate of being in the IG for the difference T1-T0 or T2-T0, CI = confidence interval, SD = standard deviation, CAU = care-as-usual, IG = intervention group, OR odds ratio for improvement in the IG compared to CAU between baseline and T1 or T2. 1 Patient Activation Measure: scores from 0 to 100 with higher scores representing better patient activation. 2 Medication adherence: scores from 5 to 25 with higher scores representing better adherence. 3 Adequate physical activity: at least 150 minutes of exercise per week. Supplementary file 1: Crude analyses

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