Annette Westgeest

1 Introduction and outline of the thesis 11
Part I Optimization of MRSA decolonization 22
2 Exploring the barriers in the uptake of the Dutch MRSA ‘search and destroy’ policy using the cascade of care approach 24
3 Eradication of community-onset MRSA carriage: a narrative review 42
4 Complicated carriage with methicillin-resistant Staphylococcus aureus: evaluation of the effectiveness of decolonization regimens advised in the Dutch national guideline 64
5 Genetic determinants in MRSA carriage and their association with decolonization outcome 82
Part II Challenges in S. aureus bacteremia management 110
6 Global differences in the management of Staphylococcus aureus bacteremia: no international standard of care 112
7 Acute kidney injury in Staphylococcus aureus bacteremia 144
8 Persistent MRSA bacteremia: host, pathogen and treatment 158
9 The association of female sex with management and mortality in patients with Staphylococcus aureus bacteremia 192
10 Female sex and mortality in patients with Staphylococcus aureus bacteremia: a systematic review and meta-analysis 214
11 Summary and general discussion 250
Nederlandse samenvatting 262
Acknowledgements 268
List of publications 270
Curriculum Vitae 272

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