91 Genetic determinants in MRSA carriage 5 Figure 3. Ciprofloxacin MIC according to MRSA decolonization outcome and mutations associated with ciprofloxacin resistance. MIC range depicted by decolonization outcome and the presence of mutations (in GrlA, GrlB, or GyrA) associated with ciprofloxacin resistance. In the isolates of patients with treatment failure (red, n = 12), mutations were identified in 7/12 (58.3%) of the isolates, whereas in the isolates of patients with successful decolonization (green, n = 44), mutations were identified in 13/44 (29.5%) isolates. In isolates with high resistance (i.e., MIC > = 8mg/L) to ciprofloxacin (n = 9), multiple mutations were detected (Table S3), except for 1 isolate without mutations. Table 3. Resistance genes Genes Treatment failure Successful decolonization P N = 12 (%) N = 44 (%) erm(C) 4 (33.3) 7 (15.9) 0.22 erm(B) 0 (0) 1 (2.3) 1.00 erm(A) 2 (16.7) 7 (15.9) 1.00 tet(K) 4 (33.3) 13 (29.5) 1.00 tet(L) 1 (8.3) 0 (0) 0.21 tet(M) 0 (0) 5 (11.4) 0.57 tet(S/M) 0 (0) 5 (11.4) 0.57 dfrG 0 (0) 4 (9.1) 0.57 dfrK 0 (0) 1 (2.3) 1.00 fus(B) 0 (0) 1 (2.3) 1.00 fus(C) 2 (16.7) 4 (9.1) 0.60 Resistance genes stratified by decolonization outcome. No genes associated with mupirocin resistance were detected
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