75 Effectiveness of MRSA decolonization regimens 4 Table 5: Univariate and multivariable analysis of predictive variables for failure of first decolonization attempt Univariate analysis Multivariable analysis Variable OR (95%CI) p-value B OR (95%CI) p-value Patient characteristics Age >60y 0.68 (0.23-1.98) 0.61 Male sex 1.54 (0.66-3.58) 0.39 Part of a known household cluster 2.38 (1.01-5.61) 0.05 0.60 1.83 (0.74-4.51) 0.19 Healthcare worker 0.54 (0.15-1.99) 0.56 Comorbidities Immunocompromised status 6.27 (1.81-21.68) <0.01 1.58 4.83 (1.34-17.45) 0.02 Current skin disease 0.66 (0.21-2.11) 0.59 Chronic antibiotic use 1.83 (0.32-10.53) 0.61 MRSA infection* 1.29 (0.54-3.08) 0.65 Site of colonization other than nose~ Throat culture positive 0.84 (0.34-2.11) 0.81 0.07 1.07 (0.39-2.96) 0.89 Perineum culture positive 1.51 (0.62-3.71) 0.39 0.40 1.49 (0.57-3.90) 0.42 Other site culture positive 1.20 (0.49-2.97) 0.81 PVL genes PVL positive 1.56 (0.49-4.93) 0.54 Legend: Results of univariate and multivariable analyses. Values are OR=odds ratio (95%CI= 95% confidence interval), B= regression coefficients. PVL= Panton Valentine Leucocidin. *MRSA infection = culture confirmed infection(s) with MRSA during colonization. ~ = Sites of colonization reflects positive cultures at screening. Multiple sites could be positive within one patient.
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