51 Eradication of community-onset MRSA carriage 3 Table 2. Randomized trials on systemic MRSA decolonization treatment Author, year Country N Population Treatments Duration1 Followup1 Culture site(s)* Decolonized at end of follow-up Eum, 2021 [31] Canada 98 Outpatients and inpatients 1. Mupirocin + chx 2. Mupirocin + chx + rifampin + doxycycline 7 365 N,P,W 1. 32% 2. 50% (p 0.04) Lindgren, 2018 [30] Sweden 52 Outpatients with throat colonization 1. Mupirocin + chx + rifampin + clindamycin/ SXT 2. Mupirocin + chx 7 180 N,T,P,W 1. 61% 2. 13% (p <0.01) Simor, 2007 [62] Canada 146 Inpatients 1. Mupirocin + chx + rifampin + doxycycline 2. No treatment 7 90 N,P,W,D 1. 74% 2. 32% (p <0.01) Chang, 2000 [65] Taiwan 16 ICU patients 1. Fusidic acid 2. No treatment 7 28 N,T,W,S 1. 33% 2. 50% (p 0.95) Parras, 1995 [69] Spain 84 13% HCW and 87% inpatients 1. Mupirocin + chx 2. SXT + topical fusidic acid + chx 5 28 N 1. 96% 2. 95% (p >0.05) Muder, 1994 [64] US 35 Long term care facility residents 1. Rifampin 2. Minocycline 3. Rifampin + minocycline 4. No treatment 5 90 N,U,W 1. 67% 2. 38% 3. 50% 4. 14% Walsh, 1993 [70] US 94 HCWs and inpatients 1. Novobiocin + rifampin 2. SXT + rifampin 7 14 N,G,W, S 1. 67% 2. 53% (p 0.18) Peterson, 1990 [71] US 21 Inpatients 1. Ciprofloxacin + rifampin 2. SXT + rifampin 14 180 N,G,W 1. 27% 2. 40% (p >0.1) Legend. 1 In days. 2 N = nasal, A = axilla, G = groin, T = throat, P = perineum/rectum, W = wounds/skin lesions, S = sputum, U = urine, D = medical device or catheter exit site. Chx = chlorhexidine. SXT = trimethoprim/sulfamethoxazole. ICU = intensive care unit. HCW = healthcare worker
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