48 Chapter 3 Table 1. Randomized trials on topical MRSA decolonization treatment Author, year Country N Population Treatments Durationa Follow upa Culture site(s)b Decolonized Other outcome Miller, 2023 [51] US 2121 Inpatients, postdischarge 1. Education 2. + mupirocin + chx 2x/month 5 days for 6 months 270 N,T,A, G,W 1. 57% 2. 73% (p <0.01) Poovelikunnel, 2018 [57] Ireland 100 14% outpatients 86% inpatients 1. Medicalgrade honey + Tricolsan 2. Mupirocin + Tricolsan 5 shortterm N, G, W 1. 43% 2. 57% (p 0.20) Received 2 treatment courses: 1. 78% 2. 20% Landelle, 2016 [59] Switzerland 146 Inpatients 1. Polyhexanide 2. Placebo 10 28 N, G 1. 34% 2. 29% (p 0.56) Cluzet, 2016 [53] US 149 Households with SSTI 1. Education 2. + mupirocin + chx 3. + mupirocin + chx + reminders 7 180 N,A,G 1. +-80% 2. +-80% 3. +-80% Time to clearance: 1. 19 days 2+3. 23 days Weintrob, 2015 [52] US 49 Outpatients with HIV 1. Mupirocin + chx 2. Placebo 7 180 N,A,G, T,P 1. 67% 2. 67% Fritz, 2011 [28] US 300 Patients with SSTI + MSSA/MRSA colonization 1. Education 2. + mupirocin 3. + mupirocin + chx 4. + mupirocin + bleach baths 5 120 N,A,G 1. 48% 2. 56% (p 0.40) 3. 54% (p 0.51) 4. 71% (p 0.02) Nasal decolonization: 1. 50% 2. 77% (p <0.01) 3. 76% (p <0.01) 4. 85% (p <0.01) Ellis, 2007 [49] US 134 Healthy soldiers 1. Mupirocin 2. Placebo 5 56 N 1. 88% 2. 65% Wendt, 2007 [26] Germany 114 In- and outpatients, nursing home residents 1. Mupirocin + chx 2. Mupirocin + placebo 5 30 N,T,G, P 1. 8% (p 0.47) 2. 13% Groin decolonization: 1. 93% (p <0.01) 2. 82% Dryden, 2004 [58] UK 224 Inpatients 1. Mupirocin + chx 2. Tea tree oil 5 14 N,T,G, S,W 1. 49% 2. 42% (p 0.03) Nasal decolonization: 1. 86% 2. 58% (p <0.01) Mody, 2003 [45] US 127 Long term care facility residents with MRSA/ MSSA colonization 1. Mupirocin 2. Placebo 14 30 N,W 1. 88% (p <0.01) 2. 13% Harbarth, 1999 [25] Switzerland 98 Inpatients 1. Mupirocin + chx 2. Placebo + chx 5 26 N,G,U, W 1. 25% (p 0.40) 2. 18% Nasal decolonization: 1. 44% 2. 23%
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