245 Meta-analysis female sex and mortality in SAB 10 eFigure 2. Funnel plot of studies included in the analysis of unadjusted mortality. One study in particular had an effect size that was larger than expected based on the standard error (lower left corner of plot). This study demonstrated significantly lower mortality in females relative to males. Despite this, Egger’s test did not reveal significant asymmetry in the funnel plot (p=0.06). Thus in total no clear evidence of publication bias was detected. eAppendix 5. Influence analysis of adjusted mortality in patients with Staphylococcus aureus bacteremia. An influence analysis showed that the overall results of the meta-analysis (i.e., association of female sex with increased mortality) did not change with removal of individual studies. OR 95%-CI p-value tau^2 tau I^2 Omitting Allard 2008 1.1757 [1.0998; 1.2568] < 0.0001 0.0117 0.1084 50.0% Omitting Austin 2020 1.1619 [1.0920; 1.2363] < 0.0001 0.0081 0.0898 44.1% Omitting Bai 2015 1.1784 [1.1021; 1.2600] < 0.0001 0.0121 0.1102 50.7% Omitting Benfield 2007 1.1956 [1.1181; 1.2785] < 0.0001 0.0109 0.1045 48.1% Omitting Benfield 2007 1.1956 [1.1164; 1.2805] < 0.0001 0.0117 0.1084 47.4% Omitting Blomfeldt 2016 1.1840 [1.1053; 1.2683] < 0.0001 0.0128 0.1132 52.2% Omitting Braquet 2016 1.1780 [1.0993; 1.2623] < 0.0001 0.0127 0.1127 50.8% Omitting Chen 2010 1.1911 [1.1132; 1.2744] < 0.0001 0.0125 0.1119 51.1% Omitting Cobussen 2018 1.1840 [1.1057; 1.2678] < 0.0001 0.0126 0.1124 52.2% Omitting Eells 2013 1.1753 [1.1026; 1.2528] < 0.0001 0.0114 0.1069 48.3% Omitting Forsblom 2018 1.1838 [1.1047; 1.2685] < 0.0001 0.0130 0.1140 52.2% Omitting Gasch 2013 1.1796 [1.1016; 1.2632] < 0.0001 0.0126 0.1123 51.4% Omitting Joo 2013 1.1837 [1.1051; 1.2678] < 0.0001 0.0128 0.1130 52.2% Omitting Kang 2018 1.1923 [1.1158; 1.2740] < 0.0001 0.0120 0.1094 50.1% Omitting Lamagni 2011 1.1953 [1.1155; 1.2807] < 0.0001 0.0122 0.1103 48.1% Omitting Laupland 2022 1.1884 [1.1061; 1.2769] < 0.0001 0.0146 0.1209 52.2% Omitting Lee 2021 1.1845 [1.1054; 1.2693] < 0.0001 0.0130 0.1142 52.2% Omitting Mansur 2012 1.1715 [1.0967; 1.2514] < 0.0001 0.0108 0.1041 48.6% Omitting Maor 2009 1.1775 [1.1024; 1.2577] < 0.0001 0.0119 0.1092 50.0% Omitting Mejer 2012 1.1911 [1.1089; 1.2793] < 0.0001 0.0143 0.1196 51.9% Omitting Mejer 2012 1.1833 [1.1016; 1.2711] < 0.0001 0.0143 0.1196 51.0% Omitting Meredith 2021 1.1864 [1.1076; 1.2708] < 0.0001 0.0129 0.1138 52.1% Omitting Murdoch 2017 1.1853 [1.1047; 1.2718] < 0.0001 0.0138 0.1174 52.2% Omitting Nambiar 2018 1.1850 [1.1042; 1.2718] < 0.0001 0.0139 0.1180 52.1% Omitting Osthoff 2016 1.1890 [1.1110; 1.2725] < 0.0001 0.0128 0.1129 51.5% Omitting Rieg 2013 1.1873 [1.1102; 1.2697] < 0.0001 0.0126 0.1124 51.2% Omitting Saunderson 2015 1.1867 [1.1080; 1.2710] < 0.0001 0.0129 0.1137 52.0% Omitting Schneider 2020 1.1820 [1.1034; 1.2661] < 0.0001 0.0128 0.1132 51.9% Omitting Smit 2017 1.1757 [1.0974; 1.2596] < 0.0001 0.0123 0.1110 49.8% Omitting Soriano 2000 1.1776 [1.1015; 1.2588] < 0.0001 0.0120 0.1096 50.4% Omitting Szubert 2019 1.1887 [1.1127; 1.2698] < 0.0001 0.0125 0.1117 50.4% Omitting Thorlacius-Ussing 2019 1.1848 [1.1028; 1.2729] < 0.0001 0.0145 0.1204 51.5% Omitting Thwaites 2010 1.1876 [1.1087; 1.2722] < 0.0001 0.0130 0.1142 52.0% Omitting Yahav 2017 1.1762 [1.0989; 1.2589] < 0.0001 0.0121 0.1100 50.4% Pooled estimate 1.1836 [1.1067; 1.2658] < 0.0001 0.0125 0.1119 50.7%
RkJQdWJsaXNoZXIy MTk4NDMw