237 Meta-analysis female sex and mortality in SAB 10 eAppendix 2. Newcastle-Ottawa Quality Assessment Scale for assessing risk of bias in observational studies. Risk of bias was assessed with the Newcastle-Ottawa Assessment Scale using the questions below. The procedure for converting the responses to an overall risk of bias assessment (i.e., low, medium, or high risk of bias) is detailed here as well. Selection 1. Representativeness of the exposed cohort a. Truly representative of the average patient with S. aureus bloodstream infection in the community (*) b. Somewhat representative of the average patient with S. aureus bloodstream infection in the community (*) c. Selected group of patients d. No description of the derivation of the cohort 2. Selection of the non-exposed cohort a. Drawn from the same community as the exposed cohort (*) b. Drawn from a different source c. No description of the derivation of the non-exposed cohort 3. Ascertainment of exposure a. Secure record (e.g. medical records) (*) b. Structured interview (*) c. Written self-report d. No description 4. Demonstration that outcome of interest was not present at start of study a. Yes (*) b. No Comparability of cohorts on basis of design or analysis 1. Study controls for level of acute illness a. Yes (*) b. No
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